Effects of Repeated Anodal tDCS Coupled With Cognitive Training for Patients With Severe Traumatic Brain Injury: A Pilot Randomized Controlled Trial
Effects of Repeated Anodal tDCS Coupled With Cognitive Training for Patients With Severe Traumatic Brain Injury: A Pilot Randomized Controlled Trial
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DOI：
10.1097/htr.0b013e318292a4c2
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发表时间：
2014-05-01
影响因子：
2.4
通讯作者：
Czlonkowska, Anna
中科院分区：
文献类型：
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作者：
Lesniak, Marcin;Polanowska, Katarzyna;Czlonkowska, Anna
目的：目的：探讨经颅阳极直流电刺激（A-tDCS）对创伤性脑损伤（TBI）患者左前额叶背外侧皮质（DLPFC）的记忆和注意力恢复的影响。设置：住院和门诊神经康复单位。参与者：23名成人患者，严重TBI后4至92个月。设计：参与者被随机分配到2组。实验组接受A-tDCS（10 min; 1 mA;在DLPFC中），随后进行康复性认知训练，每天一次，共15 d。对照组接受A-tDCS 25秒（假手术条件），具有相同的康复。主要测量指标：记忆和注意力成套测试，包括视觉和听觉模式。参与者在开始康复前（以控制自发恢复）、康复完成后和4个月后进行了两次测试。结果：两组在治疗前3周和治疗前即刻的测试评分相似。治疗后，实验组在8项认知结果测量中的6项中表现出更大的效应量，但与对照组相比无显著差异。在随访时，差异仍然不显著。结论：与以前的研究相比，我们的研究没有提供足够的证据来支持重复A-tDCS对增强严重TBI后患者记忆和注意力恢复的疗效。
Objective: To determine whether cumulative anodal transcranial direct current stimulation (A-tDCS) of the left dorsolateral prefrontal cortex (DLPFC) could enhance rehabilitation of memory and attention in patients with traumatic brain injury (TBI). Setting: Inpatient and outpatient neurorehabilitation unit. Participants: Twenty-three adult patients, 4- to 92- months post severe TBI. Design: Participants were randomly allocated to 2 groups. The experimental group received A-tDCS (10 minutes; 1 mA; in the DLPFC), followed by rehabilitative cognitive training, daily for 15 days. Controls received A-tDCS for 25 seconds (sham condition) with the same rehabilitation. Main Measures: Battery of memory and attention tests, which included visual and auditory modalities. Participants were tested twice before beginning rehabilitation (to control for spontaneous recovery), after rehabilitation completion, and 4 months later. Results: Tests scores in both groups were similar at 3 weeks before and immediately before treatment. After treatment, the experimental group exhibited larger effect sizes in 6 of 8 cognitive outcome measures, but they were not significantly different from controls. At follow-up, differences remained insignificant. Conclusion: In contrast to previous studies, our study did not provide sufficient evidence to support the efficacy of repeated A-tDCS for enhancing rehabilitation of memory and attention in patients after severe TBI.