Epidemiology and risk profile of heart failure.
Epidemiology and risk profile of heart failure.
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DOI：
10.1038/nrcardio.2010.165
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发表时间：
2011-01
影响因子：
49.6
通讯作者：
Fonarow, Gregg C.
中科院分区：
文献类型：
--
作者：
Bui, Anh L.;Horwich, Tamara B.;Fonarow, Gregg C.
心力衰竭（HF）是一个主要的公共卫生问题，在美国的患病率超过580万，在全球超过2300万，并且还在上升。发生心力衰竭的终生风险为五分之一。尽管有证据表明HF的年龄校正发病率可能已趋于稳定，但HF仍具有相当高的发病率和死亡率，5年死亡率与许多癌症相当。HF是医疗保健系统的一个相当大的负担，仅在美国每年的费用就超过390亿美元，住院率、再入院率和门诊就诊率都很高。HF不是一个单一的实体，而是一种临床综合征，根据年龄、性别、人种或种族、左心室射血分数（LVEF）状态和HF病因可能具有不同的特征。此外，在诊断为HF和LVEF降低的患者中观察到与HF和LVEF保留的患者相比的病理生理学差异，这在流行病学研究中开始得到更好的评价。许多风险因素，如缺血性心脏病、高血压、吸烟、肥胖和糖尿病等，已被确定为可预测HF的发病率及其严重程度。在这篇综述中，我们讨论了HF流行病学和风险特征的关键特征。
Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.
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影响因子：
24
作者：
Di Bari, M;Pozzi, C;Marchionni, N
通讯作者：
Marchionni, N
影响因子：
37.8
作者：
Davis BR;Kostis JB;Simpson LM;Black HR;Cushman WC;Einhorn PT;Farber MA;Ford CE;Levy D;Massie BM;Nawaz S;ALLHAT Collaborative Research Group
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ALLHAT Collaborative Research Group
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作者：
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通讯作者：
Widimsky, J
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作者：
BONNEUX, L;BARENDREGT, JJ;van der Maas, PJ
通讯作者：
van der Maas, PJ