Sensitization versus elicitation in allergic contact dermatitis: potential differences at cellular and molecular levels.
Sensitization versus elicitation in allergic contact dermatitis: potential differences at cellular and molecular levels.
复制标题
过敏性接触性皮炎的致敏与诱发：细胞和分子水平上的潜在差异。
DOI：
10.1053/ajcd.2000.8009
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Elmets,CA
中科院分区：
文献类型：
--
作者：
Xu,H;Bjarnason,B;Elmets,CA
变态反应性接触性皮炎的诱发和诱发阶段是非常复杂的过程，在许多方面都不同。许多问题仍有待调查，特别是在该疾病的诱发阶段。与变态反应性接触性皮炎的发生和维持有关的几个关键分子已经被定义，包括一些不同的细胞因子和黏附分子。人们正在尝试开发新的、更具体的药物和免疫抑制剂来抑制其活性。由于看病的患者已经致敏，进一步阐明影响过敏性接触性皮炎诱发的因素，将对该病的防治大有裨益。
The induction and elicitation phases of allergic contact dermatitis are very complicated processes that differ in many respects. Many issues remain to be investigated, especially in the elicitation phase of this disease. Several key molecules involved in the development and maintenance of allergic contact dermatitis have already been defined, including a number of different cytokines and adhesion molecules. Attempts are being made to develop new, more specific pharmacologic and immunologic inhibitors of their activity. Because patients who see a doctor are already sensitized, further elucidation of the factors affecting the elicitation of allergic contact dermatitis will greatly contribute to the prevention and treatment of the disease.