Mast cells.
Mast cells.
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DOI：
10.1007/s11894-010-0132-1
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发表时间：
2010-10-01
影响因子：
--
通讯作者：
Notari, Luigi
中科院分区：
文献类型：
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作者：
Shea-Donohue, Terez;Stiltz, Jennifer;Notari, Luigi
多年来，肥大细胞一直被认为通过释放细胞因子、趋化因子、蛋白水解酶、白三烯和生物活性多胺来特异性地参与过敏反应。肥大细胞的新角色最近已被确定，这突显了它们在先天性免疫和获得性免疫中的相关性。肥大细胞在许多不同的过程中发挥作用，包括清除肠道病原体、食物过敏、内脏过敏和肠癌。肥大细胞的激活可以引发炎症反应，这些反应在某些情况下是挽救生命的(如线虫感染)，但在另一些情况下则危及生命(如过敏)。近年来，肥大细胞及其产物以及肥大细胞活动受微环境调控的机制成为研究的主要领域。这篇综述文章的目的是总结和强调肥大细胞生物学中与肠道内稳态和病理学相关的最新发现。
Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity. Mast cells play a role in many different processes, including clearance of enteric pathogens, food allergies, visceral hypersensitivity, and intestinal cancer. The activation of mast cells can initiate inflammatory reactions that are life-saving in some circumstances (eg, nematode infection) but life-threatening in others (eg, allergy). In recent years, mast cells, their products, and the mechanisms by which mast cell activity can be regulated by the microenvironment are a major area of investigation. The purpose of this review article is to summarize and highlight the latest findings in mast cell biology associated with intestinal homeostasis and pathologies.