Temperament in velocardiofacial syndrome
Temperament in velocardiofacial syndrome
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DOI：
10.1111/j.1365-2788.2006.00859.x
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发表时间：
2007-03-01
影响因子：
3.6
通讯作者：
Kates, W. R.
中科院分区：
文献类型：
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作者：
Antshel, K. M.;Stallone, K.;Kates, W. R.
背景 腭心面综合征（VCFS）是一种由 22q11.2 染色体缺失引起的微缺失综合征。方法在本研究中，父母报告了自己的气质以及孩子的气质。 67 名 VCFS 儿童（平均年龄 = 10.8，SD = 2.8；范围 6-15）以及年龄、种族和性别比例匹配的 47 名社区对照参与者样本（平均年龄 = 10.4，SD = 2.6；范围 6-15）和 18 名兄弟姐妹对照参与者（平均年龄 = 12.1，SD = 1.9；范围 9-15）参加了当前的研究项目.结果 患有 VCFS 的儿童的气质可以用“适度困难”来形容最为贴切。虽然患有 VCFS 的参与者在所有气质领域都没有变得更加困难，但患有 VCFS 的孩子被父母评为：（1）日常习惯不太规律（例如每天在同一时间吃饭等）； (2) 注意力难以集中/持续； (3) 不太愉快/愉快； (4) 不太可能长时间从事某项活动； (5) 对环境变化的灵活反应能力较差。结论 VCFS 儿童行为症状的父母报告的最佳预测因素是父母和孩子在一般活动水平和情绪领域的气质之间的一致性较差。
Background Velocardiofacial syndrome (VCFS) is a microdeletion syndrome caused by a 22q11.2 chromosomal deletion.Methods In this study, parents reported on their own temperament as well as the temperament of their child. Sixty-seven children with VCFS (mean age = 10.8, SD = 2.8; range 6-15), and age-, race- and gender-ratio matched samples of 47 community control participants (mean age = 10.4, SD = 2.6; range 6-15), and 18 sibling control participants (mean age = 12.1, SD = 1.9; range 9-15) took part in the current project.Results Children with VCFS have a temperament that may best be described as modestly difficult; while participants with VCFS were not more difficult across all temperamental domains, children with VCFS were rated by their parents as being: (1) less regular in their daily habits (e.g. eating at the same time each day, etc.); (2) less able to focus/sustain attention; (3) less cheerful/pleasant; (4) less likely to stay with an activity for a long time; and (5) less able to respond flexibly to changes in the environment.Conclusions The best predictors of parent report of behavioural symptoms in children with VCFS were poor concordance between parent and child temperament across general activity level and mood domains.