Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium
Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium
复制标题
有氧运动通过调节主动脉内皮细胞中的 miR-492/抵抗素轴预防胰岛素抵抗
DOI：
10.1007/s12265-018-9828-7
复制
发表时间：
2018-12-01
影响因子：
3.4
通讯作者：
Liu, Sui-Xin
中科院分区：
文献类型：
--
作者：
Cai, Ying;Xie, Kang-Ling;Liu, Sui-Xin
先前，我们发现miR-492通过作为抵抗素的上游调节剂来延缓动脉粥样硬化（AS）的进展。因此，我们假设运动的抗动脉粥样硬化作用与mir -492介导的抵抗素下调和内皮损伤修复有关。在这项研究中，我们通过游泳运动研究了miR-492/抵抗素轴对改善ApoE−/−小鼠（ApoE缺陷/敲除C57BL/6小鼠）内皮损伤的影响。我们的研究结果表明，游泳运动显著降低了这些小鼠的AS和胰岛素抵抗（IR）的严重程度。此外，ApoE−/−小鼠主动脉内皮中miR-492的表达降低，抵抗素水平升高。有趣的是，游泳运动增加了miR-492的表达，同时降低了抵抗素的表达。综上所述，游泳运动可能通过上调miR-492和下调主动脉内皮中的抵抗素来延缓AS的进展。因此，运动可以调节糖脂代谢，减轻内皮IR，修复内皮损伤。
Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we investigated the effects of the miR-492/resistin axis on improving endothelial injury in ApoE−/− mice (ApoE-deficient/knockout in C57BL/6 mice) through swimming exercises. Our results showed that the severity of AS and insulin resistance (IR) in these mice were significantly reduced by swimming exercises. In addition, miR-492 expression in the aortic endothelium of ApoE−/− mice was decreased, in addition to increased levels of resistin. Interestingly, swimming exercises increased miR-492 expression while decreasing that of resistin. Taken together, swimming exercises delayed the progression of AS, possibly by upregulating miR-492 and downregulating resistin in aortic endothelium. Therefore, exercises modulated glucose and lipid metabolism, alleviated endothelial IR, and repaired endothelial injury.