Serum VEGF increases in diabetic polyneuropathy, particularly in the neurologically active symptomatic stage
Serum VEGF increases in diabetic polyneuropathy, particularly in the neurologically active symptomatic stage
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DOI：
10.1111/j.1464-5491.2009.02680.x
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发表时间：
2009-03-01
影响因子：
3.5
通讯作者：
Arimura, K.
中科院分区：
文献类型：
--
作者：
Deguchi, T.;Hashiguchi, T.;Arimura, K.
为探讨血管内皮生长因子（VEGF）与糖尿病性多发性神经病（DPN）的关系，对220例糖尿病患者（113例合并DPN，107例不合并DPN）进行了研究。所有患者还根据DPN的四个阶段进行分类（无神经病变：0期;无症状神经病变：1期;症状性神经病变：2期;致残性神经病变：3期）。采用酶联免疫吸附试验（ELISA）检测血清VEGF浓度，并比较DPN患者与非DPN患者以及DPN不同分期患者的血清VEGF水平，所有患者的平均血清VEGF水平为264.6 ± 218.8 pg/ml。DPN患者血清VEGF水平（310.1 ± 224.3 pg/ml）高于非DPN患者（216.5 ± 204.0 pg/ml，P = 0.0014）。与“无症状”（1期，256.7 +/- 224.4 pg/ml，P = 0.015）和“致残”（3期，180.3 +/- 109.4 pg/ml，P = 0.042）阶段相比，“症状”阶段（2期，364.8 +/- 225.9 pg/ml）的血清VEGF更高。糖尿病视网膜病变患者（261.1 ± 210.6 pg/ml）和糖尿病肾病患者（241.5 ± 185.7 pg/ml）的平均血清VEGF水平没有增加。
To identify the relationship between vascular endothelial growth factor (VEGF) and diabetic polyneuropathy (DPN).Two hundred and twenty diabetic patients participated, 113 with DPN and 107 without DPN. All patients were also classified according to the four stages of DPN (no neuropathy: stage 0; asymptomatic neuropathy: stage 1; symptomatic neuropathy: stage 2; disabling neuropathy: stage 3). Serum VEGF concentration was measured using an enzyme-linked immunosorbent assay (ELISA) and levels between the patients with and without DPN and also between the different stages of DPN, were compared.The mean serum VEGF level in all patients was 264.6 +/- 218.8 pg/ml. The mean serum VEGF level was higher in patients with DPN (310.1 +/- 224.3 pg/ml) than in the patients without DPN (216.5 +/- 204.0 pg/ml, P = 0.0014). Serum VEGF was higher in the 'symptomatic' stage (stage 2, 364.8 +/- 225.9 pg/ml) in comparison with the 'asymptomatic' (stage 1, 256.7 +/- 224.4 pg/ml, P = 0.015) and 'disabling' (stage 3, 180.3 +/- 109.4 pg/ml, P = 0.042) stages. The mean serum VEGF level in patients with diabetic retinopathy (261.1 +/- 210.6 pg/ml) and in patients with diabetic nephropathy (241.5 +/- 185.7 pg/ml) was not increased.The serum VEGF level is increased in patients with DPN, particularly in patients in the neurologically active 'symptomatic' stage.