Development and Validation of a Multivariable Lung Cancer Risk Prediction Model That Includes Low-Dose Computed Tomography Screening Results
Development and Validation of a Multivariable Lung Cancer Risk Prediction Model That Includes Low-Dose Computed Tomography Screening Results
复制标题
包括低剂量计算机断层扫描筛查结果的多变量肺癌风险预测模型的开发和验证
作者：
M. Tammemägi;K. ten Haaf;I. Toumazis;C. Kong;Summer S. Han;Jihyoun Jeon;J. Commins;T. Riley;R. Meza
关键问题在这项来自国家肺部筛查试验(NLST)的数据研究中，肺癌风险模型的预测能否通过纳入肺癌筛查结果而得到改善？在对包括22 229名参与者的NLST数据的二次分析中，一个整合了经过验证的肺癌风险预测模型-PLCOm2012模型的模型，与国家肺筛查试验结果(PLCO2012结果)相结合，对未来肺癌的预测明显好于排除结果的模型。这意味着PLCO2012结果模型估计可能会改善肺癌筛查患者的高风险和低风险分层，并可能有助于指导有关筛查间隔的决策。
Key Points Question In this study of data from the National Lung Screening Trial (NLST), can a lung cancer risk model’s prediction be improved by inclusion of lung cancer screening results? Findings In this secondary analysis of NLST data including 22 229 participants, a model incorporating a validated lung cancer risk prediction model, the PLCOm2012 model, with National Lung Screening Trial results (PLCO2012results) predicted future lung cancer significantly better than a model excluding results. Meaning The PLCO2012results model estimates may improve stratification of patients being screened for lung cancer into high- and low-risk strata and may help guide decision making regarding screening interval.
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影响因子：
120.7
作者：
Bach, Peter B.;Mirkin, Joshua N.;Oliver, Thomas K.;Azzoli, Christopher G.;Berry, Donald A.;Brawley, Otis W.;Byers, Tim;Colditz, Graham A.;Gould, Michael K.;Jett, James R.;Sabichi, Anita L.;Smith-Bindman, Rebecca;Wood, Douglas E.;Qaseem, Amir;Detterbeck, Frank C.
通讯作者：
Detterbeck, Frank C.
影响因子：
51.1
作者：
Patz, Edward F., Jr.;Greco, Erin;Gatsonis, Constantine;Pinsky, Paul;Kramer, Barnett S.;Aberle, Denise R.
通讯作者：
Aberle, Denise R.
DOI：
10.1056/nejmoa1301851
发表时间：
2013-07-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kovalchik SA;Tammemagi M;Berg CD;Caporaso NE;Riley TL;Korch M;Silvestri GA;Chaturvedi AK;Katki HA
通讯作者：
Katki HA
DOI：
10.1056/nejmoa1211776
发表时间：
2013-02-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tammemägi MC;Katki HA;Hocking WG;Church TR;Caporaso N;Kvale PA;Chaturvedi AK;Silvestri GA;Riley TL;Commins J;Berg CD
通讯作者：
Berg CD
影响因子：
19.7
作者：
Gatsonis, Constantine A.
通讯作者：
Gatsonis, Constantine A.