Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release
Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release
复制标题
上临界溶液温度聚合物接枝中空介孔二氧化硅纳米粒子用于近红外照射药物释放
DOI：
10.1039/c9tb01071h
复制
发表时间：
2019-10-14
影响因子：
7
通讯作者：
Tong, Zaizai
中科院分区：
文献类型：
--
作者：
Hu, Wei;Bai, Xiaowen;Tong, Zaizai
近红外辐射响应给药系统具有许多优点，引起了研究者的广泛兴趣。在本研究中，通过在中空介孔二氧化硅纳米粒子（HMSNs）表面接枝上临界溶解温度（UCST）聚合物，然后用光热转换剂吲哚菁绿色（ICG）处理，建立了近红外触发的药物释放系统。如此制备的UCST聚合物显示出45 ° C的清除温度，这有利于在生理环境（37 ° C）中充当看门人。在NIR照射下，由于ICG的存在，溶液的温度升高到澄清点以上;因此，塌陷的UCST聚合物链变得更加亲水;这导致HMSN的介孔通道暴露并实现突发药物释放。此外，这种NIR响应的递送系统在暴露于NIR辐射时显示出良好的生物相容性和对MCF-7癌细胞的高抗癌效率。此外，由于癌细胞比正常细胞更容易受到高温的影响，因此通过应用NIR辐射实现了热治疗和化学治疗的协同效应。
Near-infrared (NIR) irradiation responsive drug delivery systems have many advantages, which have attracted extensive interest from researchers. In this study, a NIR-triggered drug release system was established by grafting upper critical solution temperature (UCST) polymers on the surface of hollow mesoporous silica nanoparticles (HMSNs) followed by treatment with the photothermal conversion agent indocyanine green (ICG). The as-prepared UCST polymers showed the clearing temperature of 45 degrees C, which were advantageous to serve as gatekeepers in the physiological environment (37 degrees C). Under NIR irradiation, the temperature of the solution was elevated above the clearing point due to the presence of ICG; consequently, the collapsed UCST polymer chains became more hydrophilic; this resulted in the exposure of the mesoporous channels of the HMSNs and achievement of a burst drug release. Moreover, this NIR-responsive delivery system showed good biocompatibility and high anticancer efficiency towards the MCF-7 cancer cells upon exposure to NIR irradiation. In addition, a synergistic effect of thermal and chemo treatment has been achieved by the application of NIR irradiation since cancer cells are more vulnerable to high temperatures than normal cells.