LACTATE VULNERABILITY AFTER ALPRAZOLAM VERSUS PLACEBO-TREATMENT OF PANIC DISORDER
LACTATE VULNERABILITY AFTER ALPRAZOLAM VERSUS PLACEBO-TREATMENT OF PANIC DISORDER
复制标题
DOI：
10.1016/0006-3223(91)90069-x
复制
发表时间：
1991-07-01
影响因子：
10.6
通讯作者：
DUNNER, DL
中科院分区：
文献类型：
--
作者：
COWLEY, DS;DAGER, SR;DUNNER, DL
36例惊恐障碍患者在阿普唑仑或安慰剂治疗8周前后分别输注乳酸钠。通过主观症状评分、出现乳酸诱导症状高峰前的输注时间以及出现乳酸诱导焦虑或恐慌的患者比例来衡量，经慢性阿普唑仑治疗后无恐慌的患者对乳酸的反应性明显降低。对安慰剂无恐慌的患者，以及对阿普唑仑治疗无反应的患者，在再输注时对乳酸的反应性有所下降，尽管不那么明显。作为一个整体，安慰剂治疗的患者在临床上没有变化，再输注后乳酸反应没有系统性变化。虽然每个治疗结果组的患者数量较少，无法得出明确的结论，但这些发现表明，在阿普唑仑成功治疗恐慌后，乳酸诱导的恐慌减少可能是临床状态改变和药物直接作用的综合结果。
Thirty-six patients with panic disorder underwent sodium lactate infusion before and after 8 weeks of treatment with alprazolam or placebo. With reinfusion, those patients panic-free with chronic alprazolam treatment displayed significantly decreased reactivity to lactate, as measured by subjective symptom ratings, duration of infusion before developing peak lactate-induced symptoms, and the proportion of patients experiencing lactate-induced anxiety or panic. Patients panic-free on placebo, as well as nonresponders to alprazolam treatment, displayed some, although less striking, decreases in reactivity to lactate with reinfusion. As a group, patients clinically unchanged with placebo treatment showed no systematic change in lactate response with reinfusion. Although the small numbers of patients in each treatment outcome group prohibit drawing definitive conclusions, these findings suggest that decreases in lactate-induced panic after successful alprazolam treatment of panic may result from a combination of changes in clinical state and direct effects of the medication.