Synthetic studies toward the mannopeptimycins: synthesis of orthogonally protected beta-hydroxyenduracididines.

Synthetic studies toward the mannopeptimycins: synthesis of orthogonally protected beta-hydroxyenduracididines.
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甘露肽霉素的合成研究:正交保护的β-羟基enduracididines的合成。

DOI:
10.1021/ol100219a
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发表时间:
2010
期刊:
影响因子:
5.2
通讯作者:
VanNieuwenhze,MichaelS
VanNieuwenhze,MichaelS
中科院分区:
化学1区
文献类型:
--
作者:
Olivier,KevinS;VanNieuwenhze,MichaelS

文献摘要

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The asymmetric synthesis of the nonproteinogenic amino acids (2S,3S,4′S)-β-hydroxyenduracididine3and (2R,3S,4′S)-β-hydroxyenduracididine4in orthogonally protected form in 15 total steps from Garner’s aldehyde is reported. The former andN-glycosylated form of the latter are found in the glycopeptide antibiotic mannopeptimycin.