Oscillator death in coupled biochemical oscillators
Oscillator death in coupled biochemical oscillators
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DOI：
10.1007/s00498-023-00348-3
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发表时间：
2023-04
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影响因子：
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通讯作者：
Tomáš Gedeon;Breschine Cummins
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作者：
Tomáš Gedeon;Breschine Cummins
昼夜节律、细胞分裂和代谢振荡都是有节奏的细胞行为，它们既要健壮，又要对环境的变化做出反应。在这项工作中，我们研究耦合生化振荡器的紧急行为，建模为再减压器。虽然更传统的振荡器同步方法通常使用相位振荡器，但我们的方法使用的开关系统可能更适合由生化开关控制的细胞网络动态。我们表明，单向耦合保持了单个稳压器的稳定振荡，而相互耦合的稳压器存在良好表征的参数区，振荡停止。在其他参数下，关节振荡继续。我们的研究结果可能对理解调节网络的条件依赖性耦合和非耦合具有启示意义。
Circadian rhythm, cell division and metabolic oscillations are rhythmic cellular behaviors that must be both robust but also to respond to changes in their environment. In this work, we study emergent behavior of coupled biochemical oscillators, modeled as repressilators. While more traditional approaches to oscillators synchronization often use phase oscillators, our approach uses switching systems that may be more appropriate for cellular networks dynamics governed by biochemical switches. We show that while one-directional coupling maintains stable oscillation of individual repressilators, there are well-characterized parameter regimes of mutually coupled repressilators, where oscillations stop. In other parameter regimes, joint oscillations continue. Our results may have implications for the understanding of condition-dependent coupling and un-coupling of regulatory networks.