Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia
Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia
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DOI：
10.1186/1471-2458-12-537
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发表时间：
2012-07-23
影响因子：
4.5
通讯作者：
Aseffa, Abraham
中科院分区：
文献类型：
--
作者：
Berhe, Gebretsadik;Enquselassie, Fikre;Aseffa, Abraham
背景资料：监测结核病治疗效果，了解治疗效果不佳的具体原因，对评价结核病控制项目的效果具有重要意义。本研究调查了结核病治疗结果和不成功的治疗结果的预测因素在Tigray region of Ethiopia.Methods：2009年9月至2011年6月在埃塞俄比亚北方Tigray地区的15个区登记的涂阳肺结核（PTB）患者的病历进行了审查。其他数据的收集使用结构化的问卷调查，通过挨家挨户的访问，由受过培训的护士。结核病治疗结果根据WHO指南进行评估。结果：407例15岁以上肺结核患者（男221例，女186例）中，治疗成功率为89.2%，治疗失败率为10.8%。在最终的多变量逻辑模型中，40岁以上的患者治疗结果不成功的几率更高（调整OR = 2.50，95% CI：1.12-5.59），家庭规模大于5人（调整OR = 3.26，95% CI：1.43-7.44），失业（调整OR = 3.10，95% CI：1.33-7.24）和复治病例中（adj. OR = 2.00，95%CI：1.37-2.92）相比，其各自的比较groups.Conclusions：痰涂片阳性的肺结核患者的治疗结果是令人满意的埃塞俄比亚提格雷地区。尽管如此，那些有不良治疗结果高风险的患者应及早识别，并给予额外的随访和社会支持。
Background: Monitoring the outcome of tuberculosis treatment and understanding the specific reasons for unsuccessful treatment outcome are important in evaluating the effectiveness of tuberculosis control program. This study investigated tuberculosis treatment outcomes and predictors for unsuccessful treatment outcome in the Tigray region of Ethiopia.Methods: Medical records of smear-positive pulmonary tuberculosis (PTB) patients registered from September 2009 to June 2011 in 15 districts of Tigray region, Northern Ethiopia, were reviewed. Additional data were collected using a structured questionnaire administered through house-to-house visits by trained nurses. Tuberculosis treatment outcomes were assessed according to WHO guidelines. The association of unsuccessful treatment outcome with socio-demographic and clinical factors was analyzed using logistic regression model.Results: Out of the 407 PTB patients (221 males and 186 females) aged 15 years and above, 89.2% had successful and 10.8% had unsuccessful treatment outcome. In the final multivariate logistic model, the odds of unsuccessful treatment outcome was higher among patients older than 40 years of age (adj. OR = 2.50, 95% CI: 1.12-5.59), family size greater than 5 persons (adj. OR = 3.26, 95% CI: 1.43-7.44), unemployed (adj. OR = 3.10, 95% CI: 1.33-7.24) and among retreatment cases (adj. OR = 2.00, 95% CI: 1.37-2.92) as compared to their respective comparison groups.Conclusions: Treatment outcome among smear-positive PTB patients was satisfactory in the Tigray region of Ethiopia. Nonetheless, those patients at high risk of an unfavorable treatment outcome should be identified early and given additional follow-up and social support.