Aplastic anemia: assessment of myeloid progenitor cells in the bone marrow and blood provides prognostic information.
Aplastic anemia: assessment of myeloid progenitor cells in the bone marrow and blood provides prognostic information.
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再生障碍性贫血：对骨髓和血液中的骨髓祖细胞的评估可提供预后信息。
DOI：
10.1159/000206263
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发表时间：
1985
影响因子：
2.4
通讯作者：
E. Kabrna
中科院分区：
文献类型：
--
作者：
W. Hinterberger;K. Geissler;M. Fischer;K. Lechner;E. Kabrna
对15例再生障碍性贫血患者进行了骨髓和血液中髓系祖细胞的检测。治疗包括雄激素，低或高剂量类固醇和标准化的支持治疗。中位生存期为5.8个月。当根据患者血液和骨髓中存在的髓系祖细胞数量对患者进行分组时，我们发现，与这些细胞数量较低的患者相比，祖细胞数量较高的再生障碍患者的生存时间延长。当患者根据“生长”和“无生长”分组时，从这种体外培养中获得的预后信息特别具有指示性：与细胞保持其集落形成能力的患者相比，缺乏集落形成骨髓干细胞与生存时间显著缩短相关。除了髓系祖细胞的初始数量外，只有粒细胞的初始数量与存活时间有关。因此，测量骨髓和血液中的髓系祖细胞可以预测再生障碍性贫血患者的预后价值。
15 patients with aplastic anemia were prospectively followed after having measurements of myeloid progenitor cells in bone marrow and blood. Treatment included androgens, low or high dose steroids and standardized supportive care. The median length of survival was 5.8 months. When patients were grouped according to the numbers of myeloid progenitor cells present in their blood and bone marrow, we found that the survival length of aplastic patients with higher progenitor cell numbers was prolonged when compared to that of patients with lower numbers of these cells. The prognostic information obtained from such in vitro cultures was particularly indicative when the patients were grouped according to 'growth' and 'no growth': the absence of colony-forming myeloid stem cells was associated with survival times significantly shorter than those of patients whose cells maintained their colony-forming capacity. Besides initial numbers of myeloid progenitor cells, only initial numbers of granulocytes were related to survival length. Thus, the measurement of myeloid progenitor cells in bone marrow and blood can be of prognostic value in patients with aplastic anemia.