Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.
Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.
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DOI：
10.1111/j.1349-7006.1990.tb02636.x
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发表时间：
1990-08
期刊：
影响因子：
--
通讯作者：
Mori S
中科院分区：
文献类型：
--
作者：
Sugawara I;Hamada H;Tsuruo T;Mori S
本文描述了P-糖蛋白(P-gp)在中枢神经系统的细胞和超微结构定位。在超微结构水平上，P-gp严格局限于构成脑和脊髓毛细血管的内皮细胞的管腔表面。其他脏器内皮细胞均未见P-gp表达。我们的发现可能有助于定义血脑屏障，并暗示血脑屏障的解剖学特征是连续的无窗内皮细胞之间存在细胞间的紧密连接。
This communication describes the cellular and ultrastructural localization in the central nervous system of P‐glycoprotein (P‐GP) recognized by a murine monoclonal antibody, MRK 16. At the ultrastructural level P‐GP was strictly confined to the luminal surface of the endothelial cells which comprise the capillary vessels of the brain and the spinal cord. No P‐GP was found in the endothelial cells of other organs. Our findings may be useful as a means to define the blood‐brain barrier, and they imply that the blood‐brain barrier is anatomically characterized by the presence of intercellular tight junctions between continuous nonfenestrated endothelial cells.