Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
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DOI：
10.1016/j.cell.2007.02.040
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发表时间：
2007-04-20
期刊：
影响因子：
64.5
通讯作者：
Arendt, Detlev
中科院分区：
文献类型：
--
作者：
Denes, Alexandru S.;Jekely, Gaspar;Arendt, Detlev
为了阐明神经系统集中化的进化起源，我们研究了环节动物Platynereis dumerilli躯干神经系统的分子结构。环节动物属于双边动物，双边动物的进化谱系，也包括脊椎动物和昆虫。比较神经系统的发展环节动物的其他bilaterians可以提供有价值的信息，所有Bilateria的共同祖先。我们发现，Platynereis神经外胚层被细分为纵向祖域部分重叠的nk和pax基因的表达区域。这些结构域与脊椎动物神经管中的相应结构域相匹配，并产生保守的神经细胞类型。与脊椎动物一样，神经模式基因对Bmp信号传导敏感。我们的数据表明，这种中外侧结构存在于最后一个共同的双侧祖先，从而支持神经系统集中在双侧的共同起源。
To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilli. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous system development in annelids to that of other bilaterians could provide valuable information about the common ancestor of all Bilateria. We find that the Platynereis neuroectoderm is subdivided into longitudinal progenitor domains by partially overlapping expression regions of nk and pax genes. These domains match corresponding domains in the vertebrate neural tube and give rise to conserved neural cell types. As in vertebrates, neural patterning genes are sensitive to Bmp signaling. Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria.