Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival.
Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival.
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DOI：
10.1038/bjc.2011.166
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发表时间：
2011-06-07
影响因子：
8.8
通讯作者：
Sasaguri, Y.
中科院分区：
文献类型：
--
作者：
Li, Z.;Yamada, S.;Inenaga, S.;Imamura, T.;Wu, Y.;Wang, K-Y;Shimajiri, S.;Nakano, R.;Izumi, H.;Kohno, K.;Sasaguri, Y.
多肽N-乙酰半乳糖胺转移酶家族(GalNAc-ts)负责癌症中糖基化的改变。本研究旨在探讨GalNAc-T6和-T3两种异构体的临床意义及其与胰腺癌预后的关系。应用免疫组织化学方法检测70例临床病理特征的胰腺癌组织中GalNAc-T6和-T3的表达。免疫组织化学显示GalNAc-T6和-T3的阳性表达分别为51%(36/70)和77%(54/70)。GalNAc-T6阳性表达与病理高/中分化类型(P=0.001)、小肿瘤大小(P=0.044)、无血管侵犯(P=0.009)和美国肿瘤系统联合委员会的低分期(P=0.043)密切相关。GalNAc-T3的表达与肿瘤的分化程度显著相关(P=0.001)，而与其他临床病理特征无关。单因素和多因素分析显示GalNAc-T6的表达是判断预后的独立指标，而GalNAc-T3的表达不影响临床预后，尽管在36例GalNAc-T6阳性的病例中有33例GalNAc-T3也呈阳性表达(P=0.001，r=0.356)。GalNAc-T6和-T3的表达均与胰腺癌的分化程度密切相关，而只有GalNAc-T6的表达预测胰腺癌的预后。
The family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) is responsible for the altered glycosylation in cancer. The purpose of our study was to investigate the clinical significance of two isoforms, GalNAc-T6 and -T3, and their correlation with the prognosis of pancreatic cancer. Immunohistochemistry was used to analyse GalNAc-T6 and -T3 expressions in 70 clinicopathologically characterised pancreatic cancer cases. Positive expressions of GalNAc-T6 and -T3 were immunohistochemically identified in 51% (36 of 70) and in 77% (54 of 70) of patients, respectively. A close relationship was noted between GalNAc-T6 positive expression and pathological well/moderate differentiated type (P=0.001), small tumour size (P=0.044), absence of vascular invasion (P=0.009), and low stage of the American Joint Committee on Cancer systems (P=0.043). The expression of GalNAc-T3 significantly correlated with good differentiation (P=0.001), but not with other clinicopathologic features. Furthermore, univariate and multivariate analyses revealed that GalNAc-T6 expression was an independent prognosis indicator for the disease, whereas GalNAc-T3 expression had no impact on clinical outcome, even though 33 of 36 GalNAc-T6-positive cases also had a positive expression of GalNAc-T3 (P=0.001, r=0.356). Both GalNAc-T6 and -T3 expressions correlated significantly with tumour differentiation, whereas only GalNAc-T6 expression predicted prognosis in pancreatic cancer.
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影响因子：
6.4
作者：
Freire, Teresa;Berois, Nora;Osinaga, Eduardo
通讯作者：
Osinaga, Eduardo
影响因子：
2.9
作者：
BROCKHAUSEN, I;MOLLER, G;PAULSEN, H
通讯作者：
PAULSEN, H
影响因子：
4.8
作者：
Bennett, EP;Hassan, H;Clausen, H
通讯作者：
Clausen, H
DOI：
10.1016/j.jamcollsurg.2004.01.008
发表时间：
2004-05-01
影响因子：
5.2
作者：
Cleary, SP;Gryfe, R;Gallinger, S
通讯作者：
Gallinger, S
影响因子：
4.3
作者：
Marth, JD
通讯作者：
Marth, JD