Bergmann Glia Function in Granule Cell Migration During Cerebellum Development
Bergmann Glia Function in Granule Cell Migration During Cerebellum Development
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DOI：
10.1007/s12035-013-8405-y
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发表时间：
2013-01
影响因子：
5.1
通讯作者：
Haiwei Xu;Yang Yang-Yang;Xiaotong Tang;Meina Zhao;Fucheng Liang;P. Xu;Baoke Hou;Y. Xing;Xiaohang Bao;Xiaotang Fan
中科院分区：
文献类型：
--
作者：
Haiwei Xu;Yang Yang-Yang;Xiaotong Tang;Meina Zhao;Fucheng Liang;P. Xu;Baoke Hou;Y. Xing;Xiaohang Bao;Xiaotang Fan
颗粒细胞迁移影响小脑的层状结构，从而影响小脑功能。伯格曼胶质细胞来源于放射状胶质细胞，并通过提供迁移支架和介导伯格曼胶质细胞与颗粒细胞之间的相互作用来帮助颗粒细胞径向迁移。本文就伯格曼胶质细胞的特征及其影响小脑颗粒神经元径向迁移的机制作一综述。此外，我们将集中讨论涉及胶质细胞介导的径向迁移的重要因素，以便我们可以阐明伯格曼胶质细胞在小脑发育过程中影响颗粒细胞迁移的可能机制途径。
Granule cell migration influences the laminar structure of the cerebellum and thereby affects cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell radial migration by providing a scaffold for migration and by mediating interactions between Bergmann glia and granule cells. In this review, we summarize Bergmann glia characteristics and the mechanisms underlying the effect of Bergmann glia on the radial migration of granule neurons in the cerebellum. Furthermore, we will focus our discussion on the important factors involved in glia-mediated radial migration so that we may elucidate the possible mechanistic pathways used by Bergmann glia to influence granule cell migration during cerebellum development.