INVIVO NMR IMAGING OF NA-23 IN THE HUMAN HEAD
INVIVO NMR IMAGING OF NA-23 IN THE HUMAN HEAD
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DOI：
10.1097/00004728-198501000-00001
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发表时间：
1985-01-01
影响因子：
1.3
通讯作者：
MUN, SK
中科院分区：
文献类型：
--
作者：
HILAL, SK;MAUDSLEY, AA;MUN, SK
本文首次报道了正常人和各种病理性病变患者脑钠分布的临床核磁共振（NMR）图像。使用1.5T NMR磁体系统。当与蛋白质分布相比时，Na在组织与组织之间以及在正常与病理条件之间的浓度显示出更大的变化。基于Na浓度计算的图像对比度比蛋白质自旋密度大7-18倍。正常图像强调细胞外室。在临床研究中，新近或陈旧性脑梗塞和肿瘤区域显示出Na含量显著增加（300-400%）。图像密度值的实际测量结果表明，梗死组织中Na的NMR可见度增加可能会进一步加重对比度。钠成像可能被证明是一个更敏感的手段，为早期发现一些大脑疾病比其他成像方法。
The 1st clinical nuclear magnetic resonance (NMR) images of cerebral Na distribution in normal volunteers and in patients with a variety of pathological lesions is reported. A 1.5 T NMR magnet system was used. When compared with protein distribution, Na shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of Na concentration is 7-18 times greater than that of protein spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of Na content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased NMR visibility of Na in infarcted tissue. Na imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.