Spatially organized spike correlation in cat visual cortex
Spatially organized spike correlation in cat visual cortex
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DOI：
10.1016/j.neucom.2006.10.141
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发表时间：
2007-06-01
期刊：
影响因子：
6
通讯作者：
Gruen, Sonja
中科院分区：
文献类型：
--
作者：
Berger, Denise;Warren, David;Gruen, Sonja
从显示定向选择性地图的视觉皮质的光学记录以及当神经元自发放电时发现非常相似的群体活动模式的发现[T.Kenet，D.Bibitchkov，M.Tsodyks，A.Grinvald，A.Arieli，自发出现的视觉属性的皮质表征，自然425(2003)954-956]，我们探讨了皮层地图的概念如何与时间编码的概念相关的问题。为此，我们分析了使用覆盖3.6 mm x 3.6 mm猫视皮质区域的10 x 10电极网格进行的平行棘波记录，以发生棘波相关。我们通过互相关计算多单位活动(MUA)之间所有可能的成对相关性，并使用引导程序提取显著相关的对。相关配对中涉及的MUA通常涉及不止一个相关配对。利用图论的方法，我们发现整个相关的MUA分解成相互关联的对高度重叠的少量MUA组，将这些组映射到记录电极的空间排列上，发现这些组也对应于空间分离的簇。该相关图的空间尺度与光学成像发现的定向调谐图的尺度一致。(C)2006爱思唯尔B.V.保留所有权利。
Inspired by optical recordings from visual cortex which show maps of orientation selectivity, and the finding that very similar patterns of population activity occur when the neurons fire spontaneously [T. Kenet, D. Bibitchkov, M. Tsodyks, A. Grinvald, A. Arieli, Spontaneously emerging cortical representations of visual attributes, Nature 425 (2003) 954-956], we approach the question of how the concept of cortical maps may be related to the concept of temporal coding. To this end we analyzed parallel spike recordings performed using a 10 x 10 electrode grid covering an area of 3.6mm x 3.6mm of cat visual cortex for occurrence of spike correlation.We calculated all possible pairwise correlations between multi-unit activities (MUA) by cross-correlation and extracted significantly correlated pairs using a boot-strap procedure. The MUAs involved in correlated pairs were typically involved in more than a single correlated pair. Using methods of graph theory we found that the whole set of correlated MUAs decomposes into a small number of groups of MUAs that have a high degree of the overlap of mutually correlated pairs.Mapping these groups back onto the spatial arrangement of the recording electrodes revealed that these also correspond to spatially segregated clusters. The spatial scale of this correlation map is in agreement with the scale of orientation tuning maps found by optical imaging. (c) 2006 Elsevier B.V. All rights reserved.