Beta-Amyloid Plasma Levels in Adolescents with Anorexia Nervosa of the Restrictive Type
Beta-Amyloid Plasma Levels in Adolescents with Anorexia Nervosa of the Restrictive Type
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DOI：
10.1159/000381399
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发表时间：
2015-01-01
影响因子：
3.2
通讯作者：
Tremolizzo, Lucia
中科院分区：
文献类型：
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作者：
Conti, Elisa;Nacinovich, Renata;Tremolizzo, Lucia
背景：已知血浆瘦素减少和同型半胱氨酸 (Hcy) 升高会导致 β-淀粉样蛋白 (Aβ) 产生增加，此外也是限制性神经性厌食症 (AN) 的标志。 AN 受试者表现出多种神经精神表现，这可能导致 Aβ 介导的突触功能改变。本研究的目的在于评估 AN 患者的 Aβ 血浆水平。方法：共招募 24 名青少年女性 AN 门诊患者以及 12 名年龄相当的健康对照者。我们评估了每位受试者的 Aβ40 和瘦素血浆水平以及 APOE 基因型。还测定了接受临床表征的 AN 患者的 Hcy 血浆水平，包括饮食失调量表 3 (EDI-3)、儿童抑郁量表 (CDI) 和 BMI 下降速度估计（DPI，疾病进展指数）。结果：患者和对照组之间的血浆 A β 40 水平相似，而 AN 患者中瘦素显着降低（接近 80%）。 β 40 血浆水平与瘦素没有相关性，而与 Hcy 存在线性相关性（r = 0.50，p < 0.03）。除 DPI 外，检查的临床特征与 A beta 40 血浆水平无关（r = 0.47，p < 0.03）。结论：这项探索性研究并不支持 Aβ 产生改变在 AN 相关功能障碍中的重要作用。需要进一步的研究来澄清对于血浆 Hcy 水平显着升高的患者或进展较快的患者是否可以得出该结论的例外情况。 (C) 2015 S. Karger AG，巴塞尔
Background: Reduced plasma leptin and elevated homocysteine (Hcy) are known to lead to increased beta-amyloid (A beta) production, besides being hallmarks of anorexia nervosa (AN) of the restrictive type. AN subjects display several neuropsychiatric manifestations, which may entail A beta-mediated altered synaptic functions. The aim of this study consisted in assessing A beta plasma levels in AN patients. Methods: A total of 24 adolescent female AN outpatients were recruited together with 12 age-comparable healthy controls. For each subject we assessed A beta 40 and leptin plasma levels, as well as APOE genotype. Hcy plasma levels were also determined in AN patients who underwent clinical characterization, including the Eating Disorder Inventory-3 (EDI-3), the Children's Depression Inventory (CDI) and the estimation of the speed of BMI loss (DPI, disease progression index). Results: Plasma A beta 40 levels were similar between patients and controls, while a marked reduction was observed for leptin (similar to 80%) in AN patients. A beta 40 plasma levels failed to correlate with leptin, while a linear correlation was present with Hcy (r = 0.50, p < 0.03). Examined clinical features were not related with A beta 40 plasma levels, with the only exception of the DPI (r = 0.47, p < 0.03). Conclusion: This exploratory study does not support a significant role for altered A beta production in AN-associated dysfunctions. Further studies are required to clarify whether exceptions to this conclusion can be drawn for those patients expressing significantly elevated Hcy plasma levels or for those progressing more rapidly. (C) 2015 S. Karger AG, Basel