The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
复制标题
重度抑郁症奖励相关处理的神经关联：功能磁共振成像研究的荟萃分析。
DOI：
10.1016/j.jad.2013.06.039
复制
发表时间：
2013-11-01
影响因子：
6.6
通讯作者：
Wang, Jing
中科院分区：
文献类型：
--
作者：
Zhang, Wei-Na;Chang, Su-Hua;Wang, Jing
背景资料：越来越多的功能性磁共振成像（fMRI）研究已经在重性抑郁症（MDD）中进行，以阐明奖励相关的脑功能。这项荟萃分析的目的是研究MDD大脑中常见的奖励网络，并进一步区分积极刺激和金钱奖励以及奖励预期和结果之间的大脑激活模式。一系列激活似然估计（ALE）荟萃分析在22项功能磁共振成像研究中进行，这些研究检查了奖励相关的处理，结果：在MDD患者的额纹状体中发现了参与奖赏加工的多个脑区。共同的奖励网络在MDD的特点是减少皮层下和边缘区活动和增加皮层反应。此外，MDD患者的小脑、舌回、海马旁回和梭状回优先对正性刺激作出反应，而额叶、楔前叶、楔叶、PFC和顶下小叶则选择性地对金钱奖励作出反应。我们的研究结果表明，在金钱预期和结果阶段，尾状核反应减少，而在MDD的奖励预期过程中，额中回和背侧前扣带回的激活增加。局限性：在我们的分析中，患者的奖励相关任务和情绪状态是异质的。我们的研究结果表明，在奖励相关的加工过程中，MDD患者存在情绪或动机通路功能障碍。未来的研究可能会加强仔细注意奖励的类型，以及奖励加工的不同组成部分检查。(C)2013爱思唯尔有限公司版权所有。
Background: A growing number of functional magnetic resonance imaging (fMRI) studies have been conducted in major depressive disorder (MDD) to elucidate reward-related brain functions. The aim of this meta-analysis was to examine the common reward network in the MDD brain and to further distinguish the brain activation patterns between positive stimuli and monetary rewards as well as reward anticipation and outcome.Methods: A series of activation likelihood estimation (ALE) meta-analyses were performed across 22 fMRI studies that examined reward-related processing, with a total of 341 MDD patients and 367 healthy controls.Results: We observed several frontostriatal regions that participated in reward processing in MDD. The common reward network in MDD was characterized by decreased subcortical and limbic areas activity and an increased cortical response. In addition, the cerebellum, lingual gyms, parahippocampal gyrus and fusiform gyrus preferentially responded to positive stimuli in MDD, while the insula, precuneus, cuneus, PFC and inferior parietal lobule selectively responded to monetary rewards. Our results indicated a reduced caudate response during both monetary anticipation and outcome stages as well as increased activation in the middle frontal gyrus and dorsal anterior cingulate during reward anticipation in MDD.Limitations: The reward-related tasks and mood states of patients included in our analysis were heterogeneous.Conclusions: Our current findings suggest that there exist emotional or motivational pathway dysfunctions in MDD during reward-related processing. Future studies may be strengthened by paying careful attention to the types of reward used as well as the different components of reward processing examined. (C) 2013 Elsevier B.V. All rights reserved.