Copper-Catalyzed Geminal Difunctionalization of Terminal Alkynes by Splitting Sulfonyl Hydrazones into Two Parts.
Copper-Catalyzed Geminal Difunctionalization of Terminal Alkynes by Splitting Sulfonyl Hydrazones into Two Parts.
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DOI：
10.1021/acs.orglett.8b02268
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发表时间：
2018-08
期刊：
影响因子：
5.2
通讯作者：
Qi Sun;Linge Li;Liyan Liu;Qianqian Guan;Yu Yang;Zhenggen Zha;Zhiyong Wang
中科院分区：
文献类型：
--
作者：
Qi Sun;Linge Li;Liyan Liu;Qianqian Guan;Yu Yang;Zhenggen Zha;Zhiyong Wang
在温和的反应条件下，通过卡宾的迁移插入和磺酰基阴离子的加成，发展了Cu（I）催化端炔的偕位双官能化反应，得到了高产率和高立体选择性的乙烯基砜.
A copper(I)-catalyzed geminal difunctionalization of terminal alkynes was developed via a carbene migratory insertion and an addition of a sulfonyl anion to the triple bond at the same time under mild reaction conditions, providing a variety of vinyl sulfones with good yields and excellent stereoselectivities.