Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy
Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy
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肿瘤靶向阳性 MRI 引导化疗中整合素 αvβ3 受体过表达
DOI：
10.1021/acsami.9b16648
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发表时间：
2020-01-08
影响因子：
9.5
通讯作者：
Yang, Qing
中科院分区：
文献类型：
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作者：
Khatik, Renuka;Wang, Zhengyun;Yang, Qing
具有靶向成像和化疗功能的多功能纳米材料需求量大，挑战也很大。在此，我们合理地旨在通过RGD修饰的壳聚糖（CH）包被砷酸钆纳米针（ND）（RGD-CH-Gd-AsND）设计多功能药物递送系统。这些 ND 具有成像和靶向治疗的多功能性。静脉内给药的 ND 表明肿瘤组织中砷离子/物种的显着积累，这是通过 T-1 加权磁共振 (MR) 成像的变化进行监测的。此外，NDs 在细胞中具有高特异性，随后诱导 HepG2 细胞凋亡。因此，体内结果证明了裸鼠皮下移植异种移植模型的生物安全性、增强的肿瘤靶向性和肿瘤消退。这些 RGD-CH-Gd-AsND 具有巨大的潜力，我们预计它们可以作为实时 T-1 加权 MR 诊断和化疗的新平台。
Multifunctional nanomaterials with targeted imaging and chemotherapy have high demand with great challenge. Herein, we rationally aimed to design multifunctional drug delivery systems by RGD-modified chitosan (CH)-coated nanoneedles (NDs) of gadolinium arsenate (RGD-CH-Gd-AsNDs). These NDs have multifunctionality for imaging and targeted therapy. NDs on intravenous administration demonstrated significant accumulation of As ions/species in tumor tissues, which was monitored by the change in T-1-weighted magnetic resonance (MR) imaging. Moreover, NDs were well opsonized in cells with high specificity, subsequently inducing apoptosis to the HepG2 cells. Consequent to this, the in vivo results demonstrated biosafety, enhanced tumor targeting, and tumor regression in a subcutaneously transplanted xenograft model in nude mice. These RGD-CH-Gd-AsNDs have great potential, and we anticipate that they could serve as a novel platform for real-time T-1-weighted MR diagnosis and chemotherapy.