Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic.
Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic.
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DOI：
10.1080/21691401.2016.1241797
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Cabrales P
中科院分区：
文献类型：
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作者：
Ao-Ieong ES;Williams A;Jani V;Cabrales P
出血损害心肌收缩功能并减少氧输送。本研究探讨了聚合牛血红蛋白（PolyHb）溶液对失血性休克（HS）复苏后心功能的影响。将仓鼠用8.5 g/dL和11.5 g/dL的PolyHb复苏。在休克和复苏过程中，使用无创电导导管评估左心室（LV）功能。PolyHb复苏对心脏功能无有益影响; 8.5和11.5 g/dL时，心脏后负荷和全身血管阻力（SVR）分别增加46%和116%。研究结果表明，心脏功能的临床前评价对于开发安全有效的输血替代方案至关重要。
Hemorrhage impairs myocardial contractile function and decreases oxygen delivery. This study investigates how polymerized bovine hemoglobin (PolyHb) solutions affect cardiac function after resuscitation from hemorrhagic shock (HS). Hamsters were hemorrhaged and resuscitated with PolyHb at 8.5g/dL and 11.5 g/dL. Left ventricle (LV) function was assessed during shock and resuscitation using a miniaturize conductance catheter. PolyHb resuscitation had no beneficial effects in cardiac function; it increased cardiac afterload and systemic vascular resistance (SVR) of 46 and 116% for 8.5 and 11.5 g/dL, respectively. Study findings indicate that preclinical evaluation of cardiac function is essential to develop safe and efficacious alternatives to blood transfusion.