Deep, sub-wavelength acoustic patterning of complex and non-periodic shapes on soft membranes supported by air cavities
Deep, sub-wavelength acoustic patterning of complex and non-periodic shapes on soft membranes supported by air cavities
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DOI：
10.1039/c9lc00612e
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发表时间：
2019-11-07
期刊：
影响因子：
6.1
通讯作者：
Chiou, Pei-Yu
中科院分区：
文献类型：
--
作者：
Tung, Kuan-Wen;Chung, Pei-Shan;Chiou, Pei-Yu
液体中微物体的任意图案对许多生物医学应用至关重要。在传统的方法中，声学方法提供了优越的生物相容性，但由于驻波的性质以及流体和结构振动之间的耦合，声学方法本质上局限于在低分辨率下产生周期性图案。这项工作展示了一个能够合成高分辨率、复杂和非周期性能量势井的近场声学平台。利用一层薄的粘弹性膜，通过选择性地抑制平台上的结构振动，在深层亚波长尺度上调制声波前。使用3mhz的激发（lambda类似于水中的500 μ m），我们通过实现50 μ m（波长的十分之一）的线分辨率的微粒和细胞的图案，实验验证了这样的概念。此外，在3 x 3 mm(2)的区域内实现了大规模平行图案。这种新的声波前调制机制对复杂生物制品的生产具有重要意义。
Arbitrary patterning of micro-objects in liquid is crucial to many biomedical applications. Among conventional methodologies, acoustic approaches provide superior biocompatibility but are intrinsically limited to producing periodic patterns at low resolution due to the nature of standing waves and the coupling between fluid and structure vibrations. This work demonstrates a near-field acoustic platform capable of synthesizing high resolution, complex and non-periodic energy potential wells. A thin and viscoelastic membrane is utilized to modulate the acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. Using 3 MHz excitation (lambda similar to 500 mu m in water), we have experimentally validated such a concept by realizing patterning of microparticles and cells with a line resolution of 50 mu m (one tenth of the wavelength). Furthermore, massively parallel patterning across a 3 x 3 mm(2) area has been achieved. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.