R-Ras as a key player for signaling pathway of plexins
R-Ras as a key player for signaling pathway of plexins
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DOI：
10.1385/mn:32:3:217
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发表时间：
2005-12-01
影响因子：
5.1
通讯作者：
Katoh, H
中科院分区：
文献类型：
--
作者：
Negishi, M;Oinuma, I;Katoh, H
轴突引导是神经元网络形成的重要一步。轴突由各种引导因子引导，例如信号蛋白、狭缝、肝配蛋白和netrin。丛状蛋白是脑信号蛋白家族的排斥分子的细胞表面受体。丛蛋白的胞质区域负责启动细胞信号转导，导致轴突排斥。最近的进展揭示了plexins的信号转导机制和机制，它导致排斥反应。丛蛋白-B1具有R-Ras的内在鸟嘌呤三磷酸（GTP）酶激活蛋白活性，R-Ras是小GTP酶的Ras家族的成员，其涉及通过整合素激活促进细胞粘附和神经突生长。Sema 4D对丛蛋白B1的刺激通过下调R-Ras活性诱导生长锥的塌陷。本文综述了目前对丛蛋白信号转导机制的认识。
Axon guidance represents an important step in the formation of neuronal networks. Axons are guided by various guidance factors, such as semaphorins, slits, ephrins, and netrins. Plexins are cell surface receptors for the repulsive molecules of the semaphorin family. Cytoplasmic regions of plexins are responsible for initiating cellular signal transduction, resulting in axon repulsion. Recent advances have shed light on the signal transduction mechanism of plexins and the mechanisms by which it leads to a repulsive response. Plexin-B1 possesses an intrinsic guanine triphosphate (GTP)ase activating protein activity for R-Ras, a member of Ras family of small GTPases that has been implicated in promoting cell adhesion and neurite outgrowth through integrin activation. Stimulation of Plexin-B1 by Sema4D induces collapse of the growth cone through down-regulation of R-Ras activity. This article summarizes current understanding of the signaling mechanisms of plexins.