MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.
MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.
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DOI：
10.1038/jid.2015.167
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Parks WC
中科院分区：
文献类型：
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作者：
Rohani MG;McMahan RS;Razumova MV;Hertz AL;Cieslewicz M;Pun SH;Regnier M;Wang Y;Birkland TP;Parks WC
MMP-10 is expressed by macrophages and epithelium in response to injury, but its functions in wound repair are unknown. We observed increased collagen deposition and skin stiffness in Mmp10−/− wounds with no difference in collagen expression or re-epithelialization. Increased collagen deposition in Mmp10−/− wounds was accompanied by less collagenolytic activity and reduced expression of specific metallocollagenases, particularly MMP-8 and MMP-13, where MMP-13 was the key collagenase. Ablation and adoptive transfer approaches and cell-based models demonstrated that the MMP-10-dependent collagenolytic activity was a product of alternatively activated (M2) resident macrophages. These data demonstrate a critical role for macrophage MMP-10 in controlling the tissue remodeling activity of macrophages and moderating scar formation during wound repair.
