Microarray-based identification of novel biomarkers in asthma.
Microarray-based identification of novel biomarkers in asthma.
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DOI：
10.2332/allergolint.55.361
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发表时间：
2006-12-01
期刊：
影响因子：
--
通讯作者：
Saito, Hirohisa
中科院分区：
文献类型：
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作者：
Izuhara, Kenji;Saito, Hirohisa
支气管哮喘是一种受遗传和环境因素影响的复杂多样的疾病。广泛认为它是一种起源于肺部的Th2型炎症，由吸入普遍存在的过敏原引起。其发病机制复杂多样，尚未阐明。功能基因组学是在特定条件下对整个基因表达谱进行分析，而基因芯片技术是目前功能基因组学研究的最有力工具。利用基因芯片技术对支气管哮喘的发病机制进行了研究，为支气管哮喘的诊断、治疗靶点和发病机制的研究提供了新的生物标志物。在这篇文章中，我们回顾了这些分析的结果，微阵列的方法，适用于这种疾病的重点是识别新的生物标志物。
Bronchial asthma is a complicated and diverse disorder affected by genetic and environmental factors. It is widely accepted that it is a Th2-type inflammation originating in lung and caused by inhalation of ubiquitous allergens. The complicated and diverse pathogenesis of this disease yet to be clarified. Functional genomics is the analysis of whole gene expression profiling under given condition, and microarray technology is now the most powerful tool for functional genomics. Several attempts to clarify the pathogenesis of bronchial asthma have been carried out using microarray technology, providing us some novel biomarkers for diagnosis, therapeutic targets or understanding pathogenic mechanisms of bronchial asthma. In this article, we review the outcomes of these analyses by the microarray approach as applied to this disease by focusing on the identification of novel biomarkers.