Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats
Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats
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DOI：
10.7314/apjcp.2012.13.9.4393
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发表时间：
2012-01-01
影响因子：
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通讯作者：
Sultana, Sarwat
中科院分区：
文献类型：
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作者：
Hamiza, Oday O.;Rehman, Muneeb U.;Sultana, Sarwat
结肠癌是世界上第三大常见的恶性肿瘤，它仍然是重要的死亡原因，特别是在西方国家。有毒的环境污染物1，2-二甲基肼(DMH)也是一种结肠癌特异性致癌物质。单宁酸(TA)被报道对各种类型的化学毒性和致癌有效。在本研究中，我们评价了TA对DMH诱导的大鼠结肠毒性的化学预防效果。从抗氧化酶活性、脂质过氧化、组织病理学改变和早期炎症和促肿瘤分子标志物的表达等生化指标评价TA对结肠毒性的疗效。DMH处理诱导氧化应激酶活性(p
Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries. The toxic environmental pollutant, 1, 2-dimethylhydrazine (DMH), is also a colon-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemically induced toxicity and also carcinogenesis. In the present study, we evaluated the chemopreventive efficacy of TA against DMH induced colon toxicity in a rat model. Efficacy of TA against the colon toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, lipid peroxidation, histopathological changes and expression of early molecular markers of inflammation and tumor promotion. DMH treatment induced oxidative stress enzymes (p