Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells
Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells
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DOI：
10.1086/597801
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发表时间：
2009-05-01
影响因子：
6.4
通讯作者：
Fowke, Keith R.
中科院分区：
文献类型：
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作者：
Card, Catherine M.;McLaren, Paul J.;Fowke, Keith R.
具有人类免疫缺陷病毒 (HIV) 抵抗力的商业性工作者提供了一个独特的机会来研究与艾滋病毒感染自然抵抗力相关的保护相关性。对这些人和其他接触过艾滋病毒的未感染者的研究得出的新数据表明，低水平的免疫激活可能有助于防止感染。在本研究中，HIV 耐药个体表达激活标记 CD69 的 T 细胞频率降低。与 HIV 阴性对照个体相比，他们还发现调节性 T (T-reg) 细胞的频率较高。通过控制 T 细胞的激活水平，Treg 细胞可能会最大限度地减少易受感染的细胞库，从而有助于抵抗 HIV。
Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels of immune activation may contribute to protection against infection. In the present study, HIV-resistant individuals were shown to have reduced frequencies of T cells expressing the activation marker CD69. They were also found to have elevated frequencies of regulatory T (T-reg) cells, compared with HIV-negative control individuals. By controlling levels of T cell activation, Treg cells may contribute to HIV resistance by minimizing the pool of cells susceptible to infection.