Interhemispheric anatomical differences in human primary auditory cortex: Probabilistic mapping and volume measurement from magnetic resonance scans
Interhemispheric anatomical differences in human primary auditory cortex: Probabilistic mapping and volume measurement from magnetic resonance scans
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DOI：
10.1093/cercor/6.5.661
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发表时间：
1996-09-01
期刊：
影响因子：
3.7
通讯作者：
Evans, AC
中科院分区：
文献类型：
--
作者：
Penhune, VB;Zatorre, RJ;Evans, AC
人脑中初级听觉皮层（PAC）区域的脑回形态具有高度变异性。自本世纪初以来，人们就已经注意到大脑半球之间可能存在的不对称性。我们绘制了PAC的位置和范围，这是通过在磁共振扫描中依据大体解剖标志确定的，这些扫描已被转换到Talairach - Tournoux立体定向空间。对个体图谱进行平均，生成了该区域的概率图谱，它可与任何经过类似转换的大脑结构或功能图像进行配准。该图谱可用于在特定概率范围内定位感兴趣的区域，比如病变区域，或者正电子发射断层扫描或功能性磁共振成像中的激活焦点。我们还测量了该区域的总体积，发现无论是平均而言还是在大多数受试者中，都存在显著的左大于右的不对称性。将体积自动分割为灰质和白质后发现，左侧白质体积更大，但灰质体积并非如此。这种较大体积的皮质连接纤维可能与已知的左半球在语言方面的优势有关，并且提示左侧PAC在处理听觉刺激的时间特性方面具有优先作用。
The gyral morphology of the region of the primary auditory cortex (PAC) in the human brain is highly variable. and possible asymmetries between the hemispheres have been noted since the beginning of the century. We mapped the location and extent of PAC as identified from gross anatomical landmarks in magnetic resonance scans that had been transformed into Talairach-Tournoux stereotaxic space. Individual maps were averaged to produce a probabilistic map of the region which can be co-registered with any image of brain structure or function that has been similarly transformed. The map can be used to localize a region of interest, such as a lesion, or an activation focus from positron emission tomography or functional magnetic resonance imaging, within a specified range of probability. We also measured the total volume of the region and found a significant L > R asymmetry both on average and in the majority of subjects. Automatic segmentation of the volumes into grey and white matter revealed larger volumes of white, but not grey matter on the left. This larger volume of cortical connecting fibres may be related to the known left-hemisphere dominance for speech, and a preferential role for left PAC in processing temporal aspects of auditory stimuli is suggested.