Nanoparticle augmented radiation treatment decreases cancer cell proliferation.
Nanoparticle augmented radiation treatment decreases cancer cell proliferation.
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DOI：
10.1016/j.nano.2011.08.003
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
H. Townley;E. Rapa;G. Wakefield;P. Dobson
中科院分区：
文献类型：
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作者：
H. Townley;E. Rapa;G. Wakefield;P. Dobson
我们报告了使用新的X射线可激活的二氧化钛纳米粒子（NPs）掺杂镧系元素的显着和控制的细胞死亡。优先将这些材料掺入肿瘤组织中可以增强放射治疗的效果。在本文中，将钆并入NP中被设计为优化来自常规医学X射线的局部能量吸收。通过添加其他稀土元素进一步优化了这一结果。在辐射时，能量转移到二氧化钛晶体结构，导致活性氧物质（ROS）的产生。来自临床编辑：作者报道了使用x射线激活的掺杂镧系元素的二氧化钛纳米颗粒作为增强剂的显著和受控的细胞死亡。在照射时，X射线能量被转移到二氧化钛晶体结构，导致活性氧物质的产生。
We report significant and controlled cell death using novel x-ray-activatable titania nanoparticles (NPs) doped with lanthanides. Preferential incorporation of such materials into tumor tissue can enhance the effect of radiation therapy. Herein, the incorporation of gadolinium into the NPs is designed to optimize localized energy absorption from a conventional medical x-ray. This result is further optimized by the addition of other rare earth elements. Upon irradiation, energy is transferred to the titania crystal structure, resulting in the generation of reactive oxygen species (ROS). FROM THE CLINICAL EDITOR: The authors report significant and controlled cell death using x-ray-activated titania nanoparticles doped with lanthanides as enhancers. Upon irradiation X-ray energy is transferred to the titania crystal structure, resulting in the generation of reactive oxygen species.