Aging of the NMDA receptor: from a mouse's point of view.
Aging of the NMDA receptor: from a mouse's point of view.
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DOI：
10.2217/fnl.12.54
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发表时间：
2012-09
期刊：
影响因子：
1.3
通讯作者：
Magnusson KR
中科院分区：
文献类型：
--
作者：
Magnusson KR
我们的老年人口正在增长，认知能力的下降，如记忆力的下降，可能会付出高昂的代价，因为它会干扰一个人独立生活的能力。NMDA受体对许多不同形式的记忆非常重要，该受体受到衰老的负面影响。本文综述了最近在研究C57BL/6小鼠NMDA受体不同亚单位和剪接变异体对正常衰老的选择性易损性方面取得的进展。也有证据表明，随着年龄的增长，NMDA受体与可塑性的关系发生了变化。最近的干预措施表明，增强老年人的NMDA受体与改善记忆有关，但神经退行性疾病的小鼠模型表明，在太少和太多NMDA受体活性之间找到正确的平衡将是在不引发病理的情况下增强记忆的关键。
Our elderly population is growing and declines in cognitive abilities, such as memory, can be costly, because it can interfere with a person’s ability to live independently. The NMDA receptor is very important for many different forms of memory and this receptor is negatively affected by aging. This review examines the progress that has been made recently in characterizing selective vulnerabilities of different subunits and splice variants of the NMDA receptor to normal aging in C57BL/6 mice. Evidence is also presented for changes in the relationships of NMDA receptors to plasticity across aging. Recent interventions show that enhancing NMDA receptors in aged individuals is associated with improvements in memory, but mouse models of neurodegenerative diseases suggest that finding the right balance between too little and too much NMDA receptor activity will be the key to enhancing memory without inducing pathology.