Effects of stimulation level and electrode pairing on the binaural interaction component of the electrically evoked auditory brain stem response.
Effects of stimulation level and electrode pairing on the binaural interaction component of the electrically evoked auditory brain stem response.
复制标题
刺激水平和电极配对对电诱发听觉脑干反应的双耳相互作用成分的影响。
DOI：
10.1097/aud.0b013e3181d5d9bf
复制
发表时间：
2010-08
期刊：
影响因子：
3.7
通讯作者：
Abbas PJ
中科院分区：
文献类型：
--
作者：
He S;Brown CJ;Abbas PJ
本研究的目的是调查刺激水平和电极配对对 Nucleus 人工耳蜗使用者电诱发听觉脑干反应 (EABR) 的双耳交互成分 (BIC) 的影响。十名舌后聋成年人工耳蜗使用者参与了这项研究。 EABR 使用左单耳、右单耳和双侧刺激条件下的响度平衡双相电流脉冲进行测量。通过将右耳中的电极 12（22 个耳蜗内电极中的）与左耳中间隔开的电极阵列中的 11 个电极中的每一个配对，根据为每个受试者获得的 EABR 测量值来计算 BIC。通过测量六名受试者的 BIC 生长功能，研究刺激水平对 BIC 幅度的影响。研究了 10 名受试者在高刺激水平下和 7 名受试者在低刺激水平下电极配对对 BIC 幅度的影响。高刺激水平被选择为受试者动态范围 (DR) 的 90% 点或电生理记录未受到肌肉伪影污染的最高刺激水平。低刺激水平被选择为比这七名受试者中的六名的 BIC 阈值高 10% 的受试者 DR 点的水平。对于一名受试者，BIC 阈值不可用，低刺激水平指的是她 DR 的 70% 点。对于在两种刺激水平下测试的大多数受试者，从所有 11 个耳间电极对成功记录了 BIC。 BIC 幅度随着刺激水平的增加而增加。刺激水平对 BIC 潜伏期的影响不太明显。在高刺激水平下，当左耳使用的刺激电极发生系统变化时，BIC 振幅没有显着变化。当使用低刺激水平时，耳蜗内位置相似的耳间电极对的 BIC 幅度最大，并且当耳间电极之间的偏移增加时，BIC 幅度减小。这项研究表明刺激水平会影响 BIC 反应的幅度。即使从具有较大耳间偏移的耳间电极对，也可以记录双侧 CI 用户的 EABR 的 BIC。这一发现表明，当使用高水平刺激时，两个耳蜗内存在广泛的电流传播模式。在较低的刺激水平下，耳蜗内的兴奋传播减少，使得电极配对对 BIC 幅度的影响更加明显。
The purpose of this study was to investigate the effects of stimulation level and electrode pairing on the binaural interaction component (BIC) of the electrically evoked auditory brain stem response (EABR) in Nucleus cochlear implant users. Ten postlingually deafened adult cochlear implant users participated in this study. EABRs were measured using loudness balanced, biphasic current pulses presented in the left monaural, right monaural and bilateral stimulation conditions. BICs were computed based on measures of the EABR obtained for each subject by pairing the electrode 12 (out of 22 intracochlear electrodes) in the right ear with each of 11 electrodes spaced across the electrode array in the left ear. The effect of stimulation level on the amplitude of the BIC was investigated by measuring growth functions of the BIC from six subjects. The effect of electrode pairing on the amplitude of the BIC was studied at high stimulation levels in ten subjects and at low stimulation levels in seven subjects. The high stimulation level was chosen as the 90% point of the subject’s dynamic range (DR) or the highest stimulation level where the electrophysiological recordings were not contaminated by muscle artifacts. The low stimulation level was chosen as a level that was 10% point of subject’s DR higher than the BIC threshold for six of these seven subjects. For one subject, BIC thresholds were not available and the low stimulation level was referred to the 70% point of her DR. BICs were successfully recorded from all 11 interaural electrode pairs for a majority of subjects tested at both stimulation levels. BIC amplitudes increased with stimulation level. The effect of stimulation level on latencies of the BIC was less robust. At high stimulation levels, BIC amplitudes did not change significantly as the stimulating electrode used in the left ear was systematically varied. When low stimulation levels were used, BIC amplitude was maximal for interaural electrode pairs with similar intracochlear positions and decreased when the offset between interaural electrodes increased. This study demonstrates that stimulation level affects amplitudes of the BIC response. It is possible to record the BIC of the EABR in bilateral CI users even from interaural electrode pairs that have large interaural offsets. This finding suggests that when high-level stimuli are used, there is a broad pattern of current spread within the two cochleae. At lower stimulation levels the spread of excitation within the cochlea is reduced making the effect of electrode pairing on the amplitude of the BIC more pronounced.