Possible therapeutic effect of a Traditional Chinese Medicine, Sinisan, on chronic restraint stress related disorders
Possible therapeutic effect of a Traditional Chinese Medicine, Sinisan, on chronic restraint stress related disorders
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中药四逆散对慢性束缚应激相关疾病的可能治疗作用
DOI：
10.1016/j.neulet.2008.10.100
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发表时间：
2009-01-16
影响因子：
2.5
通讯作者：
Wang, Wen
中科院分区：
文献类型：
--
作者：
Wang, Yu-Tong;Tan, Qing-Rong;Wang, Wen
根据中国传统医学（TCM），肝脏是起源或与压力相关的疾病如抑郁症最相关。四逆散是一种常用的保肝药。我们研究了四逆散是否在实验动物模型中发挥治疗作用：慢性束缚应激（CRS）模型。四逆散以100 mg/kg的浓度在动物饮用水中给药21天（CRS前7天，CRS期间14天）。在CRS程序后24 h使用Morris水迷宫（MWM）测量空间学习和记忆。同时测定攻击行为和体重。四逆散治疗减少了攻击行为，逆转了CRS诱导的空间学习和记忆障碍以及生长速度下降。总之，我们的研究结果表明，四逆散确实发挥了可测量的治疗作用，在实验慢性应激模型。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
According to Traditional Chinese Medicine (TCM), the liver is the origin or most associated with stress related disorders such as depression. Sinisan, a TCM prescription, has been used as a hepatic protectant. We examined whether Sinisan exerts therapeutic effects in an experimental animal model: the chronic restraint stress (CRS) model. Sinisan was administered in the animal's drinking water at a concentration of 100 mg/kg for 21 days (7 days pre-CRS and 14 days during the CRS). Spatial learning and memory were measured 24 h after the CRS procedures using the Morris Water Maze (MWM). Aggressive behavior and body weight were determined as well. The Sinisan treatment decreased aggressive behaviors and reversed CRS-induced impairment of spatial learning and memory as well as decreased rate of growth. In conclusion, our results suggest that Sinisan does exert measurable therapeutic effects in an experimental chronic stress model. (c) 2008 Elsevier Ireland Ltd. All rights reserved.