Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
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DOI：
10.1038/339439a0
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发表时间：
1989-06
期刊：
影响因子：
64.8
通讯作者：
H. Takeshima;S. Nishimura;Takeshi Matsumoto;Hiroyuki Ishida;K. Kangawa;N. Minamino;H. Matsuo;M. Ueda;M. Hanaoka;T. Hirose;S. Numa
中科院分区：
文献类型：
--
作者：
H. Takeshima;S. Nishimura;Takeshi Matsumoto;Hiroyuki Ishida;K. Kangawa;N. Minamino;H. Matsuo;M. Ueda;M. Hanaoka;T. Hirose;S. Numa
通过对兔骨骼肌肌浆网ryanodine受体的互补DNA进行克隆和测序，推导出该受体的5,037个氨基酸序列。预测的结构表明，钙释放通道活性驻留在受体分子的C-末端区域，而其余部分构成的“脚”结构跨越肌浆网和横小管之间的交界处的差距。
The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.