Ischemic mitral regurgitation - Long-term outcome and prognostic implications with quantitative Doppler assessment
Ischemic mitral regurgitation - Long-term outcome and prognostic implications with quantitative Doppler assessment
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DOI：
10.1161/01.cir.103.13.1759
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发表时间：
2001-04-03
期刊：
影响因子：
37.8
通讯作者：
Tajik, AJ
中科院分区：
文献类型：
--
作者：
Grigioni, F;Enriquez-Sarano, M;Tajik, AJ
背景-心肌梗死（MI）可直接引起缺血性二尖瓣返流（IMR），这被认为是MI后急性期和早期预后不良的指标。然而，在慢性心肌梗死后阶段，IMR的存在和程度的预后意义是不明确的。（>16天）经胸超声心动图检查的ECG Q波MI：194例在常规实践中定量评估的IMR患者和109例基线年龄匹配的无LMR患者（71 ± 11岁vs 70 ± 9岁，P=0.20）、性别和射血分数（EF，33 ± 14% vs 34 ± 11%，P=0.14）。在IMR患者中，返流容积（RVR）和有效返流口（ERO）面积分别为36 +/- 24 mL/次和21 +/- 12 mm（2）。5年后，IMR患者的总死亡率和心源性死亡率（分别为62 +/-5%和50 +/-6%）高于无IMR患者（分别为39 +/-6%和30 +/-5%）（均P
Background-Myocardial infarction (MI) can directly cause ischemic mitral regurgitation (IMR), which has been touted as an indicator of poor prognosis in acute and early phases after MI. However, in the chronic post-MI phase, prognostic implications of IMR presence and degree are poorly defined.Methods and Results-We analyzed 303 patients with previous (>16 days) Q-wave MI by ECG who underwent transthoracic echocardiography: 194 with IMR quantitatively assessed in routine practice and 109 without LMR matched for baseline age (71 +/- 11 versus 70 +/-9 years, P=0.20), sex, and ejection fraction (EF, 33 +/- 14% versus 34 +/- 11%, P=0.14). In IMR patients, regurgitant volume (RVol) and effective regurgitant orifice (ERO) area were 36 +/- 24 mL/beat and 21 +/- 12 mm(2), respectively. After 5 years, total mortality and cardiac mortality for patients with IMR (62 +/-5% and 50 +/-6%, respectively) were higher than for those without IMR (39 +/-6% and 30 +/-5%, respectively) (both P