The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes
The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes
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DOI：
10.1056/nejmoa011053
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发表时间：
2001-10-04
影响因子：
158.5
通讯作者：
Braunwald, E
中科院分区：
文献类型：
--
作者：
de Lemos, JA;Morrow, DA;Braunwald, E
背景：脑（B型）钠尿肽是一种主要由心室肌合成的神经激素。虽然这种神经激素的循环水平已被证明可以为透壁性心肌梗死患者提供独立的预后信息，但对于ST段抬高不存在的急性冠状动脉综合征患者，几乎没有数据可用。我们测量了血浆标本中的B型利钠肽，平均值（+/-SD）为40+/-在2525例出现缺血症状20小时后的患者中进行了来自Orbofiban在不稳定冠状动脉综合征患者中的溶栓治疗心肌梗死16项研究。B型利钠肽的基线水平与30天和10个月时的死亡、心力衰竭和心肌梗死风险相关。随着基线B型利钠肽水平四分位数的增加，未校正的死亡率呈阶梯式增加（P
Background: Brain (B-type) natriuretic peptide is a neurohormone synthesized predominantly in ventricular myocardium. Although the circulating level of this neurohormone has been shown to provide independent prognostic information in patients with transmural myocardial infarction, few data are available for patients with acute coronary syndromes in the absence of ST-segment elevation.Methods: We measured B-type natriuretic peptide in plasma specimens obtained a mean (+/-SD) of 40+/-20 hours after the onset of ischemic symptoms in 2525 patients from the Orbofiban in Patients with Unstable Coronary Syndromes-Thrombolysis in Myocardial Infarction 16 study.Results: The base-line level of B-type natriuretic peptide was correlated with the risk of death, heart failure, and myocardial infarction at 30 days and 10 months. The unadjusted rate of death increased in a stepwise fashion among patients in increasing quartiles of base-line B-type natriuretic peptide levels (P