The Acute Inflammatory Response to Absorbed Collagen Sponge Is Not Enhanced by BMP-2.
The Acute Inflammatory Response to Absorbed Collagen Sponge Is Not Enhanced by BMP-2.
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BMP-2 不会增强对吸收的胶原海绵的急性炎症反应
DOI：
10.3390/ijms18030498
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发表时间：
2017-02-25
影响因子：
5.6
通讯作者：
Wu G
中科院分区：
文献类型：
--
作者：
Huang H;Wismeijer D;Hunziker EB;Wu G
可吸收胶原海绵（ACS）/骨形态发生蛋白-2（BMP-2）在临床上广泛用于骨再生。然而，发现该产品的应用与显著的促炎反应相关，特别是在植入后的早期阶段。本研究旨在阐明与加入ACS的BMP-2相关的促炎活性是否与载体本身的物理状态有关，即，ACS的湿润或高度脱水状态，局部血管化程度和/或局部生物力学因素。将ACS（0.8 cm直径）/BMP-2皮下植入12只8周龄Sprague道利大鼠的背部。术后2天，取出植入材料，并进行组织学和组织形态计量学分析。ACS植入后的急性炎症反应既不依赖于BMP-2的存在或不存在，也不依赖于周围组织中的血管化程度，也不依赖于植入时ACS材料的水合状态（湿与干）。在植入部位操作的差异微生物力学因素似乎对炎症厚度有影响。我们的结论是ACS/BMP-2的早期炎症反应的程度可能与载体材料本身的物理和化学性质有关。
Absorbed collagen sponge (ACS)/bone morphogenetic protein-2 (BMP-2) are widely used in clinical practise for bone regeneration. However, the application of this product was found to be associated with a significant pro-inflammatory response, particularly in the early phase after implantation. This study aimed to clarify if the pro-inflammatory activities, associated with BMP-2 added to ACS, were related to the physical state of the carrier itself, i.e., a wet or a highly dehydrated state of the ACS, to the local degree of vascularisation and/or to local biomechanical factors. ACS (0.8 cm diameter)/BMP-2 were implanted subcutaneously in the back of 12 eight-week-old Sprague Dawley rats. Two days after surgery, the implanted materials were retrieved and analysed histologically and histomorphometrically. The acute inflammatory response following implantation of ACS was dependent of neither the presence or absence of BMP-2 nor the degree of vascularization in the surrounding tissue nor the hydration state (wet versus dry) of the ACS material at the time of implantation. Differential micro biomechanical factors operating at the implantation site appeared to have an influence on the thickness of inflammation. We conclude that the degree of the early inflammatory response of the ACS/BMP-2 may be associated with the physical and chemical properties of the carrier material itself.