Renal cell carcinoma: histological classification and correlation with imaging findings.
Renal cell carcinoma: histological classification and correlation with imaging findings.
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DOI：
10.1590/0100-3984.2013.1927
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发表时间：
2015-05
影响因子：
--
通讯作者：
Prando A
中科院分区：
文献类型：
--
作者：
Muglia VF;Prando A
肾细胞癌（RCC）是西方世界第七大最常见的组织学类型癌症，其患病率持续上升。考虑到其组织学亚型的预后和治疗意义，rcc的组织学分类是至关重要的。影像学方法在RCC的诊断、分期和随访中发挥着突出的作用。透明细胞、乳头状和嫌色细胞是RCC最常见的组织学亚型，它们的术前放射学特征，无论是否随后进行确证性经皮活检，可能在手术条件差、转移性疾病、孤立肾中央性肿块以及适合分子靶向治疗的患者中特别有用。最近发展的治疗肾癌的新策略，如冷冻和射频消融，分子靶向治疗和主动监测，也需要适当的术前肾肿块特征。不太常见的组织学类型，尽管具有非特异性的影像学特征，但可根据临床和流行病学资料怀疑。本研究旨在回顾组织学RCC亚型的主要临床和影像学表现。
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.