Independent effects of waist circumference and physical activity on all-cause mortality in Canadian women
Independent effects of waist circumference and physical activity on all-cause mortality in Canadian women
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DOI：
10.1139/h05-038
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发表时间：
2006-06-01
期刊：
影响因子：
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通讯作者：
Craig, CL
中科院分区：
文献类型：
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作者：
Katzmarzyk, PT;Craig, CL
本研究的目的是确定腰围（WC）和缺乏身体活动对女性死亡风险的独立影响。这项前瞻性队列研究纳入了1981年加拿大健康调查中年龄为2069岁的5421名女性参与者。WC测量与人体测量磁带和休闲时间的体力活动水平在过去的12个月内进行了评估与问卷调查。通过与加拿大死亡率数据库的数据连接进行死亡率监测，直至1993年12月31日。使用考克斯比例风险回归估计死亡率的风险比（HR），将年龄、吸烟状况和饮酒量作为所有模型的协变量。在平均12.4年的随访（67500人-年的随访）中，共发生225例死亡。体力活动（HR = 0.78; 95% C.I.：0.64-0.95）和WC（HR = 1.17; 95% C.I.：1.05-1.31）与死亡率相关时，包括在单独的回归模型。当纳入同一模型时，体力活动（HR = 0.79; 95% CI：0.65-0.96）和WC（HR = 1.16; 95% CI：1.04-1.30）仍然是死亡率的独立显著预测因子。总之，缺乏身体活动和高WC对妇女过早死亡具有显著的独立风险。
The purpose of this study was to determine the independent effects of waist circumference (WC) and physical inactivity on the risk of mortality in women. This prospective cohort study included 5421 female participants 2069 years of age in the 1981 Canada Fitness Survey. WC was measured with an anthropometric tape and leisure-time physical activity levels over the previous 12 months were assessed with a questionnaire. Mortality surveillance was conducted by data linkage with the Canadian Mortality Database through 31 December, 1993. The hazard ratios (HR) of mortality were estimated using Cox proportional hazards regression with age, smoking status, and alcohol consumption included as covariates in all models. A total of 225 deaths occurred over an average of 12.4 years of follow up (67 500 person-years of follow up). Physical activity (HR = 0.78; 95% C.I.: 0.64-0.95) and WC (HR = 1.17; 95% C.I.: 1.05-1.31) were associated with mortality when included in separate regression models. When included in the same model, both physical activity (HR = 0.79; 95% CI: 0.65-0.96) and WC (HR = 1.16; 95% C.I.: 1.04-1.30) remained independent significant predictors of mortality. In conclusion, physical inactivity and high WC have significant independent risks of premature mortality among women.