Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholestero l Metabolism in Rats within a Short Period
Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholestero l Metabolism in Rats within a Short Period
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DOI：
10.5650/jos.ess20096
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发表时间：
2020-01-01
影响因子：
1.5
通讯作者：
Osada, Kyoichi
中科院分区：
文献类型：
--
作者：
Hayashi, Khota;Kawai, Saki;Osada, Kyoichi
人们对多酚等各种食物成分的降胆固醇作用越来越感兴趣。在这项研究中，我们研究了低聚醇--一种从荔枝果实中提取的低分子多酚--在短期给药下对大鼠胆固醇代谢的影响。灌胃给药3天后，大鼠盲肠重量明显增加，盲肠正丁酸浓度显著降低。低聚醇还显著降低肝脏胆固醇水平，增加粪便中总中性类固醇排泄水平。它还显著增加了粪便中的β-鼠李酸，而总的酸性类固醇水平保持不变。低聚醇组大鼠肝脏细胞色素P450家族7亚家族A成员1的基因表达显著增加。这种增加可能归因于回肠法尼醇X受体、小异二聚体伴侣和成纤维细胞生长因子15表达的变化。我们的数据表明，低聚醇通过抑制胆汁中胆固醇从肠道吸收和上调胆固醇分解代谢来诱导降胆固醇作用，即使在短期给药后也是如此。因此，低聚醇可能是降低胆固醇水平的重要食物成分。
There is growing research interest in the hypocholesterolemic effect of various food components such as polyphenols. In this study, we examined the effects of oligonol-a low-molecular weight polyphenol extracted from lychee fruit-on cholesterol metabolism in rats under short-term administration. Administration of oligonol for 3 days significantly increased cecum weight and decreased cecal n-butyric acid concentrations in rats. Oligonol also significantly lowered the levels of hepatic cholesterol and increased the levels of total neutral steroids excreted in the feces. It also increased fecal beta-muricholic acid significantly, whereas the levels of total acidic steroids remained unchanged. Gene expression of hepatic CYP7A1 (cytochrome P450 family 7 subfamily A member 1) significantly increased following the administration of oligonol. This increase could be ascribed to changes in the expression of farnesoid X receptor, small heterodimer partner, and fibroblast growth factor 15 in ileum. Our data suggest that oligonol induces hypocholesterolemic effects through the inhibition of biliary cholesterol absorption from the intestine and the upregulation of cholesterol catabolism in rats even following short-term administration. Therefore, oligonol may be an important food component for reducing cholesterol level.