Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
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DOI：
10.4049/jimmunol.178.11.6730
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发表时间：
2007-06-01
影响因子：
4.4
通讯作者：
Zou, Weiping
中科院分区：
文献类型：
--
作者：
Kryczek, Ilona;Wei, Shuang;Zou, Weiping
Th17细胞扮演着一个重要的角色。在炎症和自身免疫性疾病中发挥积极作用。然而，在肿瘤免疫的背景下，Th17的性质和调节仍不清楚。在这项研究中，我们发现与调节性T(Treg)细胞类似，IL-17(+)、CD4(+)和CD8(+)T细胞在多种肿瘤微环境中被动态诱导。Treg细胞在肿瘤免疫发病机制和调节免疫治疗效果中起着至关重要的作用。IL-2对Treg细胞的产生和功能至关重要。我们现在发现，在体外和体内，IL-2降低了肿瘤微环境中IL-17(+)T细胞的分化，同时伴随着增强的Treg细胞室。综上所述，我们的工作证实了IL-17(+)T细胞在肿瘤微环境中的动态分化，揭示了IL-2在控制IL-17(+)和Treg细胞之间的平衡中的新作用，并为IL-17(+)T细胞在肿瘤免疫病理和治疗中的应用提供了新的见解。
Th17 cells play an. active role in inflammation and autoimmune diseases. However, the nature and regulation of Th17 in the context of tumor immunity remain unknown. In this study, we show that parallel to regulatory T (Treg) cells, IL-17(+) CD4(+) and CD8(+) T cells are kinetically induced in multiple tumor microenvironments in mice and humans. Treg cells play a crucial role in tumor immune pathogenesis and temper immune therapeutic efficacy. IL-2 is crucial for the production and function Of Treg cells. We now show that IL-2 reduces IL-17(+) T cell differentiation in the tumor microenvironment accompanied with an enhanced Treg cell compartment in vitro and in vivo. Altogether, our work demonstrates a dynamic differentiation of IL-17(+) T cells in the tumor microenvironment, reveals a novel role for IL-2 in controlling the balance between IL-17(+) and Treg cells, and provides new insight of IL-17(+) T cells in tumor immune pathology and therapy.