Beyond sun protection factor: An approach to environmental protection with novel mineral coatings in a vehicle containing a blend of skincare ingredients
Beyond sun protection factor: An approach to environmental protection with novel mineral coatings in a vehicle containing a blend of skincare ingredients
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DOI：
10.1111/jocd.13007
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发表时间：
2020-02-01
影响因子：
2.3
通讯作者：
Bouche, Deborah
中科院分区：
文献类型：
--
作者：
Bernstein, Eric F.;Sarkas, Harry W.;Bouche, Deborah
皮肤过早老化是由暴露于一系列环境因素造成的，主要是紫外线辐射，但也包括蓝色光谱中的高能可见光、红外辐射和环境污染。这些外在因素导致活性氧的产生，从而促进光老化和导致皮肤癌的DNA损伤。目的：利用氧化锌和二氧化钛颗粒的新涂层以及免费的护肤成分来配制护肤产品，以提供广泛的保护，防止一系列环境损害。方法采用由硅酸盐、聚烷基硅氧烷和聚二甲基硅氧烷组成的交叉聚合物多功能涂层，提高了矿物防晒剂与能源相互作用时的光稳定性，降低了其反应性。这些产品还含有抗氧化剂，以减少自由基的传播。此外，这种涂层改善了矿物防晒霜的美感，同时通过混合氧化铁的配方产品增强了外观。结果一系列的体外和离体研究表明，含有新型多功能涂层的矿物基产品具有抗紫外线、高能可见光、红外辐射和环境污染的能力。结论新研制的矿物基护肤品环保、生态安全，可替代化学基防晒成分。
Background Premature skin aging results from exposure to a range of environmental factors, primarily ultraviolet radiation, but also high-energy visible light in the blue spectrum, infrared radiation, and environmental pollution. These extrinsic factors result in the generation of reactive oxygen species which promote photoaging and DNA damage resulting in skin cancers. Aims To formulate skincare products utilizing a new coating applied to zinc oxide and titanium dioxide particles and complimentary skincare ingredients to provide broad protection against a range of environmental insults. Methods A cross-polymer, multifunctional coating of silicate, polyalkylsilsesquioxane, and polydimethylsiloxane moieties increases the photostability and decreases the reactivity of mineral sunscreen agents when interacting with energy sources. These products are also formulated with antioxidants to minimize free radical propagation. Additionally, this coating improves the esthetic feel of mineral sunscreens, while the appearance is enhanced by formulating products with a blend of iron oxides. Results A series of in vitro and ex vivo studies demonstrated the ability of mineral-based products formulated with the new multifunctional coating to provide protection against ultraviolet radiation, high-energy visible light, infrared radiation, and environmental pollution. Conclusion Newly formulated mineral-based skincare products provide environmental protection, are ecologically safe, and can replace chemical-based sunscreen ingredients.