Toxoplasma gondii as a risk factor for early-onset schizophrenia:: Analysis of filter paper blood samples obtained at birth
Toxoplasma gondii as a risk factor for early-onset schizophrenia:: Analysis of filter paper blood samples obtained at birth
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DOI：
10.1016/j.biopsych.2006.05.024
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发表时间：
2007-03-01
影响因子：
10.6
通讯作者：
Yolken, Robert H.
中科院分区：
文献类型：
--
作者：
Bo Mortensen, Preben;Norgaard-Pedersen, Bent;Yolken, Robert H.
背景资料：胎儿期或新生儿期感染，包括弓形虫感染，可能与精神分裂症和其他精神障碍的风险有关。本研究的目的是研究产妇和新生儿感染的血清学标志物和精神分裂症，相关精神病和情感障碍的风险之间的关联在一个国家的新生儿队列。方法：本研究是一个队列为基础的，病例对照研究结合数据从国家人口登记和患者登记和国家新生儿筛查生物库在丹麦。患者包括1981年出生于丹麦或之后随访至1999年的精神分裂症或相关疾病住院或门诊治疗患者（ICD-10 F2）或情感障碍（ICD-10 F3）。对照组中弓形虫免疫球蛋白G（IgG）水平与精神分裂症风险显著相关（优势比[OR] = 1.79，p = 0.045）调整后的城市化的出生地，出生年份，性别，和精神病诊断的一级亲属。感染和其他精神分裂症样精神障碍或情感disorders.Conclusions：我们的研究支持弓形虫和早发性精神分裂症之间的关联之间的任何标记之间没有显着的关联。需要进一步的研究来确定这种关联是否是因果关系，以及它是否普遍适用于18岁以后发病的病例。
Background: Infections during fetal life or neonatal period, including infections with Toxoplasma gondii, may be associated with a risk for schizophrenia and other mental disorders. The objectives of this study were to study the association between serological markers for maternal and neonatal infection and the risk for schizophrenia, related psychoses, and affective disorders in a national cohort of newborns.Methods: This study was a cohort-based, case-control study combining data from national population registers and patient registers and a national neonatal screening biobank in Denmark. Patients included persons born in Denmark in 1981 or later followed up through 1999 with respect to inpatient or outpatient treatment for schizophrenia or related disorders (ICD-10 F2) or affective disorders (ICD-10 F3).Results: Toxoplasma gondii immunoglobulin G (IgG) levels corresponding to the upper quartile among control subjects were significantly associated with schizophrenia risk (odds ratio [OR] = 1.79, p =.045) after adjustment for urbanicity of place of birth, year of birth, gender, and psychiatric diagnoses among first-degree relatives. There was no significant association between any marker of infection and other schizophrenia-like disorders or affective disorders.Conclusions: Our study supports an association between Toxoplasma gondii and early-onset schizophrenia. Further studies are needed to establish if the association is causal and if it generalizes to cases with onset after age 18.