The rate and pattern of fetal hemoglobin decline adjusted to sickle cell status of newborns in Dar es Salaam, Tanzania: A prospective cohort study.
The rate and pattern of fetal hemoglobin decline adjusted to sickle cell status of newborns in Dar es Salaam, Tanzania: A prospective cohort study.
复制标题
根据坦桑尼亚达累斯萨拉姆新生儿镰状细胞状态调整胎儿血红蛋白下降的速度和模式：一项前瞻性队列研究。
DOI：
10.1002/ajh.27004
复制
发表时间：
2023
影响因子：
12.8
通讯作者：
Nkya,Siana
中科院分区：
文献类型：
--
作者：
Nyangasa,Salama;Solomon,David;Njiro,Belinda;Faisal,Anab;Makani,Julie;Nkya,Siana
全球估计表明，每年有5 476 000名携带者（HbAS）和312 000名纯合子（HbSS）出生时携带HbS基因。SCD的最高负担在非洲，每年全球30万SCD新生儿中有高达75%发生在非洲。坦桑尼亚每年有11000名婴儿出生时患有SCD，其中高达90%的婴儿在5岁之前死亡。1HbF是SCD最强的调节剂。2，3 HbF在胎儿中占主导地位，出生时浓度为65%至90%。它在出生前下降，到6至12个月时下降到不到2%，并被成人血红蛋白HbA或（对于患有SCD的婴儿）HbS所取代。然而，转换过程的确切时间和机制仍不清楚。4
To the Editor: Global estimates indicate that 5 476 000 carriers (HbAS) and 312 000 homozygous (HbSS) are born annually with the HbS gene. The highest burden of SCD is in Africa, where up to 75% of the 300 000 global births of SCD occur annually. 11 000 babies are born with SCD per year in Tanzania, and up to 90% of these babies die before the age of five. 1HbF is the most powerful modulator of SCD. 2, 3 HbF is predominant in the fetus, with a concentration of 65% to 90% at birth. It declines just before birth reaching less than 2% by 6 to 12 months of life and is replaced by either adult hemoglobin HbA or, for babies with SCD, HbS. However, the precise time and mechanism of the switching process are still unclear. 4