Cerebrospinal Fluid Levels of d‐Tubocurarine in Man
Cerebrospinal Fluid Levels of d‐Tubocurarine in Man
复制标题
人脑脊液中 d-管箭毒碱的水平
DOI：
10.1097/00000542-197706000-00004
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发表时间：
1977
期刊：
影响因子：
8.8
通讯作者：
H. Khambatta
中科院分区：
文献类型：
--
作者：
R. Matteo;E. K. Pua;H. Khambatta
用放射免疫法测定人静脉注射后脑脊液中的D-管乌拉林(DTC)。9例患者单次注射DTC(0.3 mg/kg)，5分钟内在腰脑脊液中出现少量的DTC，为3.5±0.26 ng/ml(平均值±SE)。脑脊液中DTC浓度在接下来的25min内基本保持不变，但随后开始升高，注射后30min为9.3±4.4 ng/ml，1h为14.5±4.4 ng/ml，6h为24.9±6.5 ng/ml。另一组为6名患者，每隔90分钟给予3剂DTC(0.3 mg/kg)。每次注射后脑脊液中DTC浓度均升高。在脑脊液中发现的DTC的数量不太可能对人类产生任何药理或不良反应(例如惊厥)。
Using radioimmunoassay, d-tubocurarine (dTc) was found in the cerebrospinal fluid (CSF) of man after intravenous injection. When dTc was administered in a single dose (0.3 mg/kg) to nine patients, small quantities, 3.5 ±.26 ng/ml (mean ± SE), appeared in the lumbar CSF within 5 minutes. The concentration of dTc in the CSF remained constant for the next 25 minutes, but then began to increase with time to 9.3 ± 4.4 ng/ml 30 minutes after injection, 14.5 ± 4.4 ng/ml at one hour, and 24.9 ± 6.5 ng/ml at six hours. In another group of six patients, three doses of dTc (0.3 mg/kg) were given at 90-minute intervals. Concentration of dTc in the CSF increased after each injection. The quantities of dTc found in the CSF are unlikely to produce any pharmacologic or adverse effect (e.g., convulsion) in man.