Catecholamines regulate tumor angiogenesis.
Catecholamines regulate tumor angiogenesis.
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DOI：
10.1158/0008-5472.can-08-4289
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发表时间：
2009-05-01
期刊：
影响因子：
11.2
通讯作者：
Basu S
中科院分区：
文献类型：
--
作者：
Chakroborty D;Sarkar C;Basu B;Dasgupta PS;Basu S
在血管生成的调节因子中，儿茶酚胺类神经递质最近引起了人们的兴趣，因为它们在肿瘤新生血管的调节中起着相反的作用。去甲肾上腺素和肾上腺素通过特异性肾上腺素受体作用，增加促血管生成因子的合成，从而促进肿瘤生长。相比之下，多巴胺通过其特异性D2受体作用，通过抑制血管通透性因子/血管内皮生长因子- a对肿瘤内皮细胞和骨髓源性内皮祖细胞的作用来抑制肿瘤生长。这些报告发现了新的肿瘤血管生成的内源性调节因子，也指出了一种新的和廉价的抗血管生成药物用于治疗癌症。
Among the regulators of angiogenesis, catecholamine neurotransmitters are of recent interest because of their opposite roles in the regulation of tumor neovascularization. Norepinephrine and epinephrine by acting through specific adrenoceptors increase the synthesis of proangiogenic factors, and thereby, promote tumor growth. In contrast, dopamine acting via its specific D2 receptors inhibits tumor growth by suppressing the actions of vascular permeability factor/vascular endothelial growth factor-A on both tumor endothelial and bone marrow-derived endothelial progenitor cells. These reports identify novel endogenous regulators of tumor angiogenesis and also indicate a new and an inexpensive class of antiangiogenic drugs for the treatment of cancer.