The Effects of Taurine, Taurine Homologs and Hypotaurine on Cell and Membrane Antioxidative System Alterations Caused by Type 2 Diabetes in Rat Erythrocytes
The Effects of Taurine, Taurine Homologs and Hypotaurine on Cell and Membrane Antioxidative System Alterations Caused by Type 2 Diabetes in Rat Erythrocytes
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DOI：
10.1007/978-0-387-75681-3_37
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Lau-Cam, Cesar A.
中科院分区：
文献类型：
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作者：
Gossai, Davekanand;Lau-Cam, Cesar A.
本研究比较了牛磺酸、氨基甲磺酸、高牛磺酸和亚牛磺酸改变与2型糖尿病相关的氧化应激和膜损伤指数的能力。在这项研究中，雄性Goto-Kakizaki和Wistar-Kyoto大鼠分别被允许自由进食高脂肪和正常饮食9周。在第8周结束时，每组中一半动物接受每日腹膜内剂量的硫化合物（0.612 M/kg），持续5天，最后一次给药后24小时，通过心脏穿刺抽取血样，以获得血浆和红细胞组分用于生化分析。相对于对照值，牛磺酸及其同系物减少膜损伤，细胞内丙二醛和氧化型谷胱甘肽的形成，并减少还原型谷胱甘肽和抗氧化酶的活性在糖尿病红细胞。除少数孤立情况外，所有供试化合物均具有同等保护性。
This study compared taurine, aminomethanesulfonic acid, homotaurine and hypotaurine for the ability to modify indices of oxidative stress and membrane damage associated with type 2 diabetes. In the study, male Goto-Kakizaki and Wistar-Kyoto rats were allowed free access to a high fat and normal diet, respectively, for 9 weeks. At the end of week 8, half of the animals in each group received a daily intraperitoneal dose of a sulfur compound (0.612 M/kg) for 5 days and, 24 hr after the last treatment, blood samples were withdrawn by cardiac puncture to obtain plasma and erythrocyte fractions for biochemical analyses. Relative to control values, taurine and its congeners reduced membrane damage, the formation of intracellular malondialdehyde and oxidized glutathione, and the decreases in reduced glutathione and antioxidative enzyme activities in diabetic erythrocytes. Except for a few isolated instances, all test compounds were equiprotective.